A formal model for analyzing drug combination effects and its application in TNF-alpha-induced NFkappaB pathway (Q33563358)

28 July 2017

A formal model for analyzing drug combination effects and its application in TNF-alpha-induced NFkappaB pathway (English)

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28 July 2017

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Han Yan

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28 July 2017

Bo Zhang

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2

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28 July 2017

Shao Li

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3

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28 July 2017

Qianchuan Zhao

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4

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28 July 2017

25 April 2010

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28 July 2017

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28 July 2017

4

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28 July 2017

50

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https://scigraph.springernature.com/pub.10.1186/1752-0509-4-50

28 July 2017

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The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

14 July 2018

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Combination therapy in treatment of experimental pulmonary aspergillosis: in vitro and in vivo correlations of the concentration- and dose- dependent interactions between anidulafungin and voriconazole by Bliss independence drug interaction analysis

14 July 2018

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Finding multiple target optimal intervention in disease-related molecular network.

14 July 2018

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Feedback loops shape cellular signals in space and time

14 July 2018

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Accelerated evolution of resistance in multidrug environments

14 July 2018

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Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm

14 July 2018

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Estimating parameters and hidden variables in non-linear state-space models based on ODEs for biological networks inference.

14 July 2018

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Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

14 July 2018

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Quantifying synergism/antagonism using nonlinear mixed-effects modeling: a simulation study

14 July 2018

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Interaction index and different methods for determining drug interaction in combination therapy

14 July 2018

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A mathematical approach to study combined effects of toxicants in vitro: evaluation of the Bliss independence criterion and the Loewe additivity model.

14 July 2018

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Simulation and sensitivity analysis of phosphorylation of EGFR signal transduction pathway in PC12 cell model

14 July 2018

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Strategies for dealing with incomplete information in the modeling of molecular interaction networks

14 July 2018

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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

14 July 2018

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The influence of the signal dynamics of activated form of IKK on NF-kappaB and anti-apoptotic gene expressions: a systems biology approach.

14 July 2018

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Principles: mechanisms and modeling of synergism in cellular responses

14 July 2018

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The IKK NF-kappa B system: a treasure trove for drug development

14 July 2018

1 reference

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Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway

14 July 2018

1 reference

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A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling

14 July 2018

1 reference

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The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

14 July 2018

1 reference

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Effects of geldanamycin on signaling through activator-protein 1 in hypoxic HT29 human colon adenocarcinoma cells

14 July 2018

1 reference

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NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

14 July 2018

1 reference

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Dominant signals leading to inhibitor kappaB protein degradation mediate CD40 ligand rescue of WEHI 231 immature B cells from receptor-mediated apoptosis.

14 July 2018

1 reference

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Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis

14 July 2018

1 reference

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

14 July 2018

1 reference

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Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria

14 July 2018

1 reference

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Synergy in natural medicines: implications for drug discovery

14 July 2018

1 reference

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A class of small molecules that inhibit TNFalpha-induced survival and death pathways via prevention of interactions between TNFalphaRI, TRADD, and RIP1.

31 October 2018

1 reference

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Parameter estimation in models combining signal transduction and metabolic pathways: the dependent input approach.

31 October 2018

1 reference

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Systems biology and combination therapy in the quest for clinical efficacy.

31 October 2018

1 reference

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In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics

31 October 2018

1 reference

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Generalized Equations for the Analysis of Inhibitions of Michaelis-Menten and Higher-Order Kinetic Systems with Two or More Mutually Exclusive and Nonexclusive Inhibitors

31 October 2018

1 reference

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The search for cytotoxic synergy between anticancer agents: a case of Dorothy and the ruby slippers?

31 October 2018

1 reference

12 December 2020

The problem of synergism and antagonism of combined drugs

1 reference

12 December 2020

A mathematical model of combination therapy using the EGFR signaling network

1 reference

12 December 2020

TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells

1 reference

12 December 2020

Identifiers

DOI

10.1186/1752-0509-4-50

1 reference

28 July 2017

journals/bmcsb/YanZLZ10

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

28 July 2017

1 reference