Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity (Q33566931)

28 July 2017

Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity (English)

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28 July 2017

P Suksaranjit

6

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author name string

N Poungvarin

1

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28 July 2017

J K Lee

2

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28 July 2017

V K Yechoor

3

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28 July 2017

M V Li

4

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28 July 2017

T Assavapokee

5

1 reference

28 July 2017

J J Thepsongwajja

7

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28 July 2017

P K Saha

8

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28 July 2017

K Oka

9

1 reference

28 July 2017

L Chan

10

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28 July 2017

3 March 2012

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28 July 2017

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28 July 2017

55

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28 July 2017

6

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28 July 2017

1783-1796

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https://scigraph.springernature.com/pub.10.1007/s00125-012-2506-4

28 July 2017

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cites work

Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

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ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells

14 July 2018

1 reference

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Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies

14 July 2018

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Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells

14 July 2018

1 reference

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Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells

14 July 2018

1 reference

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Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

14 July 2018

1 reference

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Glucolipotoxicity: fuel excess and beta-cell dysfunction.

14 July 2018

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Beta cells in type 2 diabetes - a crucial contribution to pathogenesis

14 July 2018

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ChREBP, a transcriptional regulator of glucose and lipid metabolism

14 July 2018

1 reference

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Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner

14 July 2018

1 reference

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Involvement of oxidative stress in the pathogenesis of diabetes

14 July 2018

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Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis

14 July 2018

1 reference

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Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell

14 July 2018

1 reference

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Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module

14 July 2018

1 reference

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Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

Oxidative stress and pancreatic beta-cell dysfunction

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

Gene expression profiling in INS-1 cells overexpressing thioredoxin-interacting protein

14 July 2018

1 reference

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ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells

14 July 2018

1 reference

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Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein

14 July 2018

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Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via a phosphoinositide 3-kinase pathway

14 July 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

14 July 2018

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

14 July 2018

1 reference

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Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

Adenovirus-mediated regulable target gene expression in vivo

14 July 2018

1 reference

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Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

14 July 2018

1 reference

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Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression

14 July 2018

1 reference

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Applications of retrovirus-mediated expression cloning

14 July 2018

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Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes.

14 July 2018

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Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4010252

Glucagon physiology and pathophysiology in the light of new advances

14 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2506-4

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2506-4

ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2506-4

Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2506-4

Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2506-4

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2506-4

Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription

21 January 2018

1 reference

12 December 2020

Long-term exposure of isolated rat islets of Langerhans to supraphysiologic glucose concentrations decreases insulin mRNA levels

1 reference

12 December 2020

Pathogenesis of type 2 diabetes mellitus

1 reference

12 December 2020

TXNIP Links Redox Circuitry to Glucose Control

1 reference

12 December 2020

Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes

1 reference

12 December 2020

2,7-dichlorofluorescin oxidation and reactive oxygen species: what does it measure?

1 reference

12 December 2020

10.1007/S00125-012-2506-4

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28 July 2017

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28 July 2017

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