Active efflux across the blood-brain barrier: role of the solute carrier family (Q33569358)

28 July 2017

1 reference

title

Active efflux across the blood-brain barrier: role of the solute carrier family (English)

1 reference

28 July 2017

1 reference

Hiroyuki Kusuhara

1

1 reference

PubMed ID

15717059

28 July 2017

Yuichi Sugiyama

series ordinal

2

1 reference

28 July 2017

1 January 2005

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28 July 2017

1 reference

28 July 2017

2

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28 July 2017

1

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28 July 2017

73-85

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Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

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1 reference

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Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump

28 July 2018

1 reference

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The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules

28 July 2018

1 reference

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28 July 2018

1 reference

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Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells

28 July 2018

1 reference

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ABC transporters and the blood-brain barrier

28 July 2018

1 reference

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Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

28 July 2018

1 reference

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How significant is the role of P-glycoprotein in drug absorption and brain uptake?

28 July 2018

1 reference

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28 July 2018

1 reference

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Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites

28 July 2018

1 reference

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Structural and functional aspects of the blood-brain barrier.

28 July 2018

1 reference

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Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

28 July 2018

1 reference

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28 July 2018

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Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats

28 July 2018

1 reference

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Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations

28 July 2018

1 reference

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Brain neurosteroids are 4th generation neuromessengers in the brain: cell biophysical analysis of steroid signal transduction

28 July 2018

1 reference

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Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine

28 July 2018

1 reference

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The SLC22 drug transporter family

28 July 2018

1 reference

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Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells

28 July 2018

1 reference

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The superfamily of organic anion transporting polypeptides

28 July 2018

1 reference

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Localisation of breast cancer resistance protein in microvessel endothelium of human brain

28 July 2018

1 reference

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Role of MRP4 and MRP5 in biology and chemotherapy

28 July 2018

1 reference

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The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans

28 July 2018

1 reference

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Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Molecular identification of a renal urate anion exchanger that regulates blood urate levels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Molecular aspects of renal anionic drug transport

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier

28 July 2018

1 reference

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Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2.

28 July 2018

1 reference

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Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus

28 July 2018

1 reference

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Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Expression, transport properties, and chromosomal location of organic anion transporter subtype 3

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Xenobiotic transport across isolated brain microvessels studied by confocal microscopy

28 July 2018

1 reference

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Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2.

28 July 2018

1 reference

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Molecular and functional characterization of organic cation/carnitine transporter family in mice

28 July 2018

1 reference

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P-Glycoprotein, a gatekeeper in the blood-brain barrier

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

28 July 2018

1 reference

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The choroid plexuses and the barriers between the blood and the cerebrospinal fluid

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

28 July 2018

1 reference

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Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Neurosteroids in the Hippocampus: Neuronal Plasticity and Memory

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Efflux of taurocholic acid across the blood-brain barrier: interaction with cyclic peptides.

28 July 2018

1 reference

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Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Kidney-specific expression of a novel mouse organic cation transporter-like protein

28 July 2018

1 reference

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Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: in vivo evidence by use of the brain efflux index method.

28 July 2018

1 reference

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Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

28 July 2018

1 reference

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Molecular aspects of hepatobiliary transport

28 July 2018

1 reference

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Multispecific amphipathic substrate transport by an organic anion transporter of human liver.

28 July 2018

1 reference

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In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier

28 July 2018

1 reference

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In vivo study of the elimination from rat brain of an intracerebrally formed xenobiotic metabolite, 1-naphthyl-beta-D-glucuronide.

28 July 2018

1 reference

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Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

28 July 2018

1 reference

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Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Drug efflux transporters in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Impact of drug transporter studies on drug discovery and development

21 January 2018

1 reference

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In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier.

21 January 2018

1 reference

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Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Saturable efflux of the peptides RC-160 and Tyr-MIF-1 by different parts of the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates

21 January 2018

1 reference

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Uptake and efflux of the peptidic delta-opioid receptor agonist

21 January 2018

1 reference

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Particle size analysis of concentrated phospholipid microemulsions I. Total intensity light scattering

21 January 2018

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https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

21 January 2018

1 reference

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Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier

21 January 2018

1 reference

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Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Involvement of multidrug resistance associated protein 1 (Mrp1) in the efflux transport of 17beta estradiol-D-17beta-glucuronide (E217betaG) across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Confocal imaging of organic anion transport in intact rat choroid plexus

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Acetyl‐L‐carnitine permeability across the blood–brain barrier and involvement of carnitine transporter OCTN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s)

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Bioerodible injectable poly(ortho ester) for tetracycline controlled delivery to periodontal pockets: preliminary trial in humans

21 January 2018

1 reference

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Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice

31 October 2018

1 reference

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Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive simian virus 40 large T-antigen gene

31 October 2018

1 reference

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Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations

31 October 2018

1 reference

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Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.

31 October 2018

1 reference

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Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier

31 October 2018

1 reference

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Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539323

Blood—Brain Barrier Genomics

31 October 2018

1 reference

https://api.crossref.org/works/10.1602%2FNEURORX.2.1.73

Brain-to-blood efflux transport of estrone-3-sulfate at the blood-brain barrier in rats

21 January 2018

1 reference

12 December 2020

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

1 reference

12 December 2020

Facilitated transport of benzylpenicillin through the blood-brain barrier in rats

1 reference

12 December 2020

Molecular pharmacology of organic cation transporters in kidney

1 reference

12 December 2020

Identifiers

DOI

10.1602/NEURORX.2.1.73

1 reference

28 July 2017

1 reference

28 July 2017

1 reference

PubMed ID

15717059