Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity (Q33571309)

28 July 2017

title

Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity (English)

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28 July 2017

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Jasmina Marjanovic

1

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28 July 2017

Dominika Chalupska

2

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28 July 2017

Caroline Patenode

3

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28 July 2017

Adam Coster

4

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Evan Arnold

5

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28 July 2017

Alice Ye

6

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28 July 2017

George Anesi

7

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28 July 2017

Ying Lu

8

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28 July 2017

Ilya Okun

9

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Sergey Tkachenko

10

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28 July 2017

Robert Haselkorn

11

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28 July 2017

Piotr Gornicki

12

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language of work or name

English

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publication date

3 May 2010

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Proceedings of the National Academy of Sciences of the United States of America

28 July 2017

number of pages

6

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based on heuristic

inferred from page(s)

published in

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volume

107

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28 July 2017

issue

20

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28 July 2017

page(s)

9093-9098

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Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

28 July 2017

cites work

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Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice

21 June 2018

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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

21 June 2018

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Single-site mutations in the carboxyltransferase domain of plastid acetyl-CoA carboxylase confer resistance to grass-specific herbicides

21 June 2018

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21 June 2018

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Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes

21 June 2018

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Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors

21 June 2018

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21 June 2018

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Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis

21 June 2018

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Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal

21 June 2018

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Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice

21 June 2018

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Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186

21 June 2018

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Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals

21 June 2018

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An isoleucine/leucine residue in the carboxyltransferase domain of acetyl-CoA carboxylase is critical for interaction with aryloxyphenoxypropionate and cyclohexanedione inhibitors

21 June 2018

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Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

21 June 2018

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21 June 2018

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Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii

21 June 2018

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Wheat cytosolic acetyl-CoA carboxylase complements an ACC1 null mutation in yeast.

21 June 2018

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21 June 2018

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Herbicide sensitivity determinant of wheat plastid acetyl-CoA carboxylase is located in a 400-amino acid fragment of the carboxyltransferase domain

21 June 2018

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Growth of Toxoplasma gondii is inhibited by aryloxyphenoxypropionate herbicides targeting acetyl-CoA carboxylase

21 June 2018

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Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms

21 June 2018

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The carboxyltransferase activity of the apicoplast acetyl-CoA carboxylase of Toxoplasma gondii is the target of aryloxyphenoxypropionate inhibitors

21 June 2018

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(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors

21 January 2018

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Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase

21 January 2018

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Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors

21 January 2018

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Purification and cloning of an esterase from the weed black-grass (Alopecurus myosuroides), which bioactivates aryloxyphenoxypropionate herbicides

21 January 2018

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21 January 2018

Identifiers

DOI

10.1073/PNAS.1003721107

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28 July 2017

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28 July 2017

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