Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation. (Q33574904)

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English	Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.	scientific article

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scholarly article

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9 February 2020

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation (English)

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9 February 2020

Monte Carlo method

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Kim L.R. Brouwer

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9 February 2020

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Jin Kyung Lee

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9 February 2020

Tracy L Marion

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9 February 2020

Koji Abe

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9 February 2020

Changwon Lim

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9 February 2020

Gary M Pollock

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2 October 2009

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9 February 2020

Journal of Pharmacology and Experimental Therapeutics

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9 February 2020

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Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

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Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

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Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review

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Mechanisms of troglitazone hepatotoxicity

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21 June 2018

Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver

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Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

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Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans

1 reference

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Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes

1 reference

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21 June 2018

Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.

1 reference

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21 June 2018

Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats.

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Pharmacokinetics of troglitazone, an antidiabetic agent: prediction of in vivo stereoselective sulfation and glucuronidation from in vitro data.

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Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect

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Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity

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Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10.

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Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile

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Steady-state pharmacokinetics and dose proportionality of troglitazone and its metabolites.

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Use of Ca2+ modulation to evaluate biliary excretion in sandwich-cultured rat hepatocytes.

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Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice

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1 reference

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10.1124/JPET.109.156653

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9 February 2020

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9 February 2020

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9 February 2020

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