A high-throughput small-molecule ligand screen targeted to agonists and antagonists of the G-protein-coupled receptor GPR54. (Q33575784)

20 February 2018

title

A high-throughput small-molecule ligand screen targeted to agonists and antagonists of the G-protein-coupled receptor GPR54. (English)

1 reference

20 February 2018

G protein-coupled receptor

main subject

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Wendy Kuohung

1

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William F. Crowley

6

object named as

William F Crowley

1 reference

20 February 2018

author name string

Maria Burnett

2

1 reference

20 February 2018

Deepa Mukhtyar

3

1 reference

20 February 2018

Eli Schuman

4

1 reference

20 February 2018

Jake Ni

5

1 reference

20 February 2018

Marcie A Glicksman

7

1 reference

20 February 2018

Ursula B Kaiser

8

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20 February 2018

publication date

10 May 2010

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20 February 2018

Journal of Biomolecular Screening

published in

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20 February 2018

volume

15

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20 February 2018

issue

5

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20 February 2018

page(s)

508-517

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20 February 2018

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Identifying nonselective hits from a homogeneous calcium assay screen

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

The GPR54 gene as a regulator of puberty

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Metastin suppresses the motility and growth of CHO cells transfected with its receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

KiSS-1, a novel human malignant melanoma metastasis-suppressor gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790198

The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

21 June 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Regulation of Kiss1 gene expression in the brain of the female mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of kisspeptins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Two common naturally occurring mutations in the human gonadotropin-releasing hormone (GnRH) receptor have differential effects on gonadotropin gene expression and on GnRH-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Characterization of the Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide, the Natural Ligand of GPR54

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110369701

Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other Gq-coupled receptors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20460252

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1177/1087057110369701

1 reference

20 February 2018

PMC publication ID

5790198

1 reference

20 February 2018

PubMed publication ID

20460252

1 reference

20 February 2018