Is thymocyte development functional in the aged? (Q33588677)

28 July 2017

title

Is thymocyte development functional in the aged? (English)

1 reference

28 July 2017

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Danielle Aw

1

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28 July 2017

Alberto B Silva

series ordinal

2

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28 July 2017

Donald B Palmer

series ordinal

3

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28 July 2017

publication date

17 February 2009

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28 July 2017

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28 July 2017

volume

1

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28 July 2017

issue

2

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28 July 2017

page(s)

146-153

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Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses

28 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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T cell development and receptor diversity during aging

21 June 2018

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21 June 2018

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Activation of thymic regeneration in mice and humans following androgen blockade

21 June 2018

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21 June 2018

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CD28 extinction in human T cells: altered functions and the program of T-cell senescence

21 June 2018

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21 June 2018

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21 June 2018

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T cell aging: naive but not young

21 June 2018

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Reduction in the developmental potential of intrathymic T cell progenitors with age

21 June 2018

1 reference

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Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

21 June 2018

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Signaling life and death in the thymus: timing is everything

21 June 2018

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Thymic selection revisited: how essential is it?

21 June 2018

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A positive look at double-negative thymocytes

21 June 2018

1 reference

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T-cell development and the CD4-CD8 lineage decision

21 June 2018

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Lymphostromal interactions in thymic development and function

21 June 2018

1 reference

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Thymic atrophy in the mouse is a soluble problem of the thymic environment.

21 June 2018

1 reference

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A central role for thymic emigrants in peripheral T cell homeostasis

21 June 2018

1 reference

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Generation of functional thymocytes in the human adult.

21 June 2018

1 reference

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The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool

21 June 2018

1 reference

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Early alpha beta T cell development in the thymus of normal and genetically altered mice

21 June 2018

1 reference

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Thymic involution with ageing: obsolescence or good housekeeping?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

T-cell development and function in gene-knockout mice

21 June 2018

1 reference

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Molecular and cellular events of T cell development

21 June 2018

1 reference

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Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4-CD8- and alpha beta TCR+NK1.1+ cells

21 June 2018

1 reference

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Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

21 June 2018

1 reference

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Growth of epithelial cells in the thymic medulla is under the control of mature T cells

21 June 2018

1 reference

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21 June 2018

1 reference

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Architectural changes in the thymus of aging mice.

21 June 2018

1 reference

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The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation.

31 October 2018

1 reference

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Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

Age-associated changes in CD90 expression on thymocytes and in TCR-dependent stages of thymocyte maturation in male rats.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

Cellular mechanism of thymic involution

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

Age-associated thymic atrophy is not associated with a deficiency in the CD44(+)CD25(-)CD3(-)CD4(-)CD8(-) thymocyte population

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

The pattern of T lymphocyte differentiation is altered during thymic involution

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

Expression of the alpha beta T-cell receptor is necessary for the generation of the thymic medulla

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

Phenotypical and morphological changes in the thymic microenvironment from ageing mice

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

Phenotypic and Immunohistological Analyses of the Human Adult Thymus: Evidence for an Active Thymus during Adult Life

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806005

The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells

31 October 2018

1 reference

12 December 2020

Intrinsic and Microenvironmental Defects Are Involved in the Age-Related Changes of Lin−c-kit+ Hematopoietic Progenitor Cells

1 reference

12 December 2020

Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets

1 reference

12 December 2020

Aged mice exhibit in vivo defective peripheral clonal deletion of D(b)/H-Y reactive CD8(+) T cells

1 reference

12 December 2020

NK1.1+ thymocytes. Adult murine CD4-, CD8- thymocytes contain an NK1.1+, CD3+, CD5hi, CD44hi, TCR-V beta 8+ subset

1 reference

12 December 2020

Changes in thymic function with age and during the treatment of HIV infection

1 reference

12 December 2020

Effects of castration on thymocyte development in two different models of thymic involution

1 reference

12 December 2020

Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice

1 reference

12 December 2020

Lymphohematopoietic progenitors do not have a synchronized defect with age-related thymic involution

1 reference

12 December 2020

Identifiers

DOI

10.18632/AGING.100027

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PMC publication ID

2806005

1 reference

28 July 2017

1 reference