The renal H+-K+-ATPases: physiology, regulation, and structure (Q33589092)

28 July 2017

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title

The renal H+-K+-ATPases: physiology, regulation, and structure (English)

1 reference

28 July 2017

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Megan M Greenlee

3

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author name string

Michelle L Gumz

1

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28 July 2017

I Jeanette Lynch

2

1 reference

28 July 2017

Brian D Cain

4

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28 July 2017

Charles S Wingo

5

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28 July 2017

29 July 2009

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American Journal of Physiology - Renal Physiology

28 July 2017

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28 July 2017

298

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28 July 2017

1

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28 July 2017

F12-21

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The gastric HK-ATPase: structure, function, and inhibition

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

The renal H+, K+-ATPases as therapeutic targets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

The gastric H,K ATPase as a drug target: past, present, and future

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Analysis of the gastric H,K ATPase for ion pathways and inhibitor binding sites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Molecular regulation and physiology of the H+,K+ -ATPases in kidney

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Phosphorylation of S955 at the protein kinase A consensus promotes maturation of the alpha subunit of the colonic H+,K+ -ATPase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Gastric H,K-ATPase as a drug target

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Loss of acidification of anterior prostate fluids in Atp12a-null mutant mice indicates that nongastric H-K-ATPase functions as proton pump in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

The non-gastric H,K-ATPase is oligomycin-sensitive and can function as an H+,NH4(+)-ATPase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Inhibitor and ion binding sites on the gastric H,K-ATPase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Structural basis of ion pumping by Ca2+-ATPase of the sarcoplasmic reticulum

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Direct activation of gastric H,K-ATPase by N-terminal protein kinase C phosphorylation. Comparison of the acute regulation mechanisms of H,K-ATPase and Na,K-ATPase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

The functional role of beta subunits in oligomeric P-type ATPases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Structure, promoter analysis, and chromosomal localization of the murine H(+)/K(+)-ATPase alpha 2 subunit gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Effects of ammonia on acid-base transport by the B-type intercalated cell

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Immunohistochemical localization of colonic H-K-ATPase to the apical membrane of connecting tubule cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Sch-28080 depletes intracellular ATP selectively in mIMCD-3 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

H+-K+-ATPases: regulation and role in pathophysiological states

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

H-K-ATPase in the RCCT-28A rabbit cortical collecting duct cell line.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Dietary K+ restriction upregulates total and Sch-28080-sensitive bicarbonate absorption in rat tIMCD.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Expression of HKalpha2 protein is increased selectively in renal medulla by chronic hypokalemia.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Low-NaCl diet increases H-K-ATPase in intercalated cells from rat cortical collecting duct.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Characterization and regulation of H-K-ATPase in intercalated cells of rabbit cortical collecting duct

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Intracellular pH regulation in the rabbit cortical collecting duct A-type intercalated cell

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Effect of hypokalemia on the abundance of HK alpha 1 and HK alpha 2 protein in the rat kidney

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Functional expression of the colonic H+,K+-ATPase alpha-subunit. Pharmacologic properties and assembly with X+,K+-ATPase beta-subunits.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Role of H(+)-K(+)-ATPase in pHi regulation in inner medullary collecting duct cells in culture

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Expression and cellular localization of mRNA encoding the "gastric" isoform of H(+)-K(+)-ATPase alpha-subunit in rat kidney.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Expression of colonic H-K-ATPase mRNA in cortical collecting duct: regulation by acid/base balance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Inhibition of gastric H+,K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2a)imidazole.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Increased blood pressure during potassium depletion in normotensive men.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. Functional evidence for proton-potassium-activated adenosine triphosphatase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Mechanisms of rubidium permeation by rabbit cortical collecting duct during potassium restriction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Rubidium absorption and proton secretion by rabbit outer medullary collecting duct via H-K-ATPase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

The cavity structure for docking the K(+)-competitive inhibitors in the gastric proton pump

21 June 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

The alpha-subunit of the colonic H+,K+-ATPase assembles with beta1-Na+,K+-ATPase in kidney and distal colon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Human nongastric H+-K+-ATPase: transport properties of ATP1al1 assembled with different beta-subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Mechanisms through which ammonia regulates cortical collecting duct net proton secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

The carbonyl group of glutamic acid-795 is essential for gastric H+,K+-ATPase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

The negative charge of glutamic acid-820 in the gastric H+,K+-ATPase alpha-subunit is essential for K+ activation of the enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

A novel N-terminal splice variant of the rat H+-K+-ATPase alpha2 subunit. Cloning, functional expression, and renal adaptive response to chronic hypokalemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Expression of gastric and colonic H(+)-K(+)-ATPase in the rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Mechanism of activation of ERK and H-K-ATPase by isoproterenol in rat cortical collecting duct

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Novel Schering and ouabain-insensitive potassium-dependent proton secretion in the mouse cortical collecting duct

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Functional identification of H-K-ATPase in intercalated cells of cortical collecting tubule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Stimulation of apical H-K-ATPase in intercalated cells of cortical collecting duct with chronic metabolic acidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Colonic H(+)-K(+)-ATPase in K(+) conservation and electrogenic Na(+) absorption during Na(+) restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Crystal structure of the calcium pump with a bound ATP analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Apical H(+)/base transporters mediating bicarbonate absorption and pH(i) regulation in the OMCD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

In vivo expression profile of a H+-K+-ATPase alpha2-subunit promoter-reporter transgene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Increased CO(2) stimulates K/Rb reabsorption mediated by H-K-ATPase in CCD of potassium-restricted rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90723.2008

Regulation of renal Na(+),K(+)-ATPase and ouabain-sensitive H(+),K(+)-ATPase by the cyclic AMP-protein kinase A signal transduction pathway.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Spectrophotometric method for the determination of renal ouabain-sensitive H+,K+-ATPase activity.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

HCO-3 reabsorption in renal collecting duct of NHE-3-deficient mouse: a compensatory response.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806118

Molecular modeling of the rabbit colonic (HKalpha2a) H+, K+ ATPase

31 October 2018

1 reference

12 December 2020

A conformation-specific interhelical salt bridge in the K+ binding site of gastric H,K-ATPase

1 reference

12 December 2020

Identification of the beta-subunit for nongastric H-K-ATPase in rat anterior prostate

1 reference

12 December 2020

Potassium supplementation in hypertensive patients with diuretic-induced hypokalemia

1 reference

12 December 2020

Ammonia and bicarbonate transport by rat cortical collecting ducts perfused in vitro.

1 reference

12 December 2020

Mild potassium depletion provokes renal sodium retention

1 reference

12 December 2020

H-K-ATPase immunoreactivity in cortical and outer medullary collecting duct

1 reference

12 December 2020

Potassium depletion exacerbates essential hypertension

1 reference

12 December 2020

Studies on the mechanism of action of A80915A, a semi-naphthoquinone natural product, as an inhibitor of gastric (H+-K+)-ATPase

1 reference

12 December 2020

H(+)-K(+)-ATPase activity in rat collecting duct segments

1 reference

12 December 2020

H-K-ATPase enhancement of Rb efflux by cortical collecting duct

1 reference

12 December 2020

Stimulation of total CO2 flux by 10% CO2 in rabbit CCD: role of an apical Sch-28080- and Ba-sensitive mechanism

1 reference

12 December 2020

Luminal acidification in K-replete OMCDi: contributions of H-K-ATPase and bafilomycin-A1-sensitive H-ATPase

1 reference

12 December 2020

Colocalization of H-ATPase and H,K-ATPase immunoreactivity in the rat kidney

1 reference

12 December 2020

Sodium acts as a potassium analog on gastric H,K-ATPase

1 reference

12 December 2020

Ouabain-sensitive and -insensitive K-ATPases in rat nephron: effect of K depletion

1 reference

12 December 2020

Regulation of H(+)-K(+)-ATPase expression in kidney

1 reference

12 December 2020

Effects of chronic hypokalemia on renal expression of the "gastric" H(+)-K(+)-ATPase alpha-subunit gene

1 reference

12 December 2020

Quantitative RT-PCR analysis of mRNAs encoding a colonic putative H, K-ATPase alpha subunit along the rat nephron: effect of K+ depletion

1 reference

12 December 2020

Functional activity of H-K-ATPase in individual cells of OMCD: localization and effect of K+ depletion

1 reference

12 December 2020

Chronic hypokalemia enhances expression of the H(+)-K(+)-ATPase alpha 2-subunit gene in renal medulla

1 reference

12 December 2020

NH+4 augments net acid secretion by a ouabain-sensitive mechanism in isolated perfused inner medullary collecting ducts

1 reference

12 December 2020

H(+)-K(+)-ATPase in rabbit cortical collecting duct B-type intercalated cell

1 reference

12 December 2020

H(+)-K(+)-ATPase mediates net acid secretion in rat terminal inner medullary collecting duct

1 reference

12 December 2020

K depletion modifies the properties of Sch-28080-sensitive K-ATPase in rat collecting duct

1 reference

12 December 2020

Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion

1 reference

12 December 2020

Ischemic-reperfusion injury in the kidney: overexpression of colonic H+-K+-ATPase and suppression of NHE-3

1 reference

12 December 2020

Na/H exchange and H-K ATPase increase distal tubule acidification in chronic alkalosis

1 reference

12 December 2020

The Na(+)-K(+)-ATPase beta 1 subunit is associated with the HK alpha 2 protein in the rat kidney

1 reference

12 December 2020

K+ depletion increases HCO3- reabsorption in OMCD by activation of colonic H(+)-K(+)-ATPase

1 reference

12 December 2020

Colonic H+-K+-ATPase is induced and mediates increased HCO3- reabsorption in inner medullary collecting duct in potassium depletion

1 reference

12 December 2020

Chloride transport by the rabbit cortical collecting duct: dependence on H,K-ATPase

1 reference

12 December 2020

Apical proton secretion by the inner stripe of the outer medullary collecting duct

1 reference

12 December 2020

Effect of dietary patterns on ambulatory blood pressure : results from the Dietary Approaches to Stop Hypertension (DASH) Trial. DASH Collaborative Research Group

1 reference

12 December 2020

Molecular identification of Sch28080-sensitive K-ATPase activities in the mouse kidney

1 reference

12 December 2020

Kidney collecting duct acid-base "regulon"

1 reference

12 December 2020

Effects of ammonia on bicarbonate transport in the cortical collecting duct

1 reference

12 December 2020

Ouabain-sensitive H,K-ATPase functions as Na,K-ATPase in apical membranes of rat distal colon

1 reference

12 December 2020

Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia

1 reference

12 December 2020

Activation of H(+)-K(+)-ATPase by CO(2) requires a basolateral Ba(2+)-sensitive pathway during K restriction

1 reference

12 December 2020

Pathways for HCO3-reabsorption in mouse medullary collecting duct segments

1 reference

12 December 2020

Immunohistochemical localization of H-K-ATPase alpha(2c)-subunit in rabbit kidney

1 reference

12 December 2020

10.1152/AJPRENAL.90723.2008

Identifiers

DOI

1 reference

28 July 2017

1 reference

28 July 2017

1 reference