Chimaeric G alpha proteins: their potential use in drug discovery (Q33594439)

28 July 2017

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title

Chimaeric G alpha proteins: their potential use in drug discovery (English)

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28 July 2017

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Milligan G

1

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PubMed ID

10203868

28 July 2017

Rees S

series ordinal

2

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28 July 2017

1 March 1999

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Trends in Pharmacological Sciences

28 July 2017

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28 July 2017

20

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28 July 2017

3

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28 July 2017

118-124

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https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

28 July 2017

1 reference

7 January 2021

Heterotrimeric G proteins: organizers of transmembrane signals

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

The many faces of G protein signaling

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https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery

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https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

G protein beta gamma subunits.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Role of subunit diversity in signaling by heterotrimeric G proteins

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https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

G protein mechanisms: insights from structural analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Specificity and functional applications of antipeptide antisera which identify G-protein alpha subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Peptides as probes for G protein signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

How receptors talk to trimeric G proteins

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https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

G16 as a universal G protein adapter: implications for agonist screening strategies.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha

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https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Controlling signaling with a specifically designed Gi-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Induction of NFAT-mediated transcription by Gq-coupled receptors in lymphoid and non-lymphoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Measurement of receptor-stimulated guanosine 5'-O-(gamma-thio)triphosphate binding by G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Pharmacological characterization of type 1alpha metabotropic glutamate receptor-stimulated [35S]-GTPgammaS binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Selective activation of a chimeric Gi1/Gs G protein alpha subunit by the human IP prostanoid receptor: analysis using agonist stimulation of high affinity GTPase activity and [35S]guanosine-5'-O-(3-thio)triphosphate binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Functional coupling of endogenous serotonin (5-HT1B) and calcitonin (C1a) receptors in CHO cells to a cyclic AMP-responsive luciferase reporter gene

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

A novel system that reports the G-proteins linked to a given receptor: a study of type 3 somatostatin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Investigation of growth hormone releasing hormone receptor structure and activity using yeast expression technologies

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Identification of effector-activating residues of Gs alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Localization of the effector-specifying regions of Gi2alpha and Gqalpha

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

Importance of N-terminal regions of G protein alpha subunits for the activation of phospholipase C in Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901320-6

7 January 2021

10.1016/S0165-6147(99)01320-6

Identifiers

DOI

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28 July 2017

1 reference

PubMed ID

10203868