Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers (Q33599811)

28 July 2017

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers (English)

1 reference

28 July 2017

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1 reference

ChEBI release 2020-05-28

Susan A Charman

16

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Michael W. Mather

object named as

Michael W Mather

4

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Jeremy Burrows

19

object named as

Jeremy N Burrows

1 reference

28 July 2017

Aaron Nilsen

1

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28 July 2017

Galen P Miley

2

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28 July 2017

Isaac P Forquer

3

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28 July 2017

Kasiram Katneni

5

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28 July 2017

Yuexin Li

6

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28 July 2017

Sovitj Pou

7

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28 July 2017

April M Pershing

8

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28 July 2017

Allison M Stickles

9

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28 July 2017

Eileen Ryan

10

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28 July 2017

Jane Xu Kelly

11

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28 July 2017

J Stone Doggett

12

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28 July 2017

Karen L White

13

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28 July 2017

David J Hinrichs

14

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28 July 2017

Rolf W Winter

15

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28 July 2017

Lev N Zakharov

17

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28 July 2017

Ian Bathurst

18

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28 July 2017

Akhil B Vaidya

20

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28 July 2017

Michael K Riscoe

21

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28 July 2017

language of work or name

English

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publication date

18 April 2014

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Journal of Medicinal Chemistry

28 July 2017

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28 July 2017

57

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28 July 2017

3818-3834

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28 July 2017

9

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Quinolone-3-diarylethers: a new class of antimalarial drug.

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Cu-catalyzed arylation of phenols: synthesis of sterically hindered and heteroaryl diaryl ethers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions: an overview

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Prodrugs: design and clinical applications.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Antimalarial quinolones: synthesis, potency, and mechanistic studies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Nanosizing--oral formulation development and biopharmaceutical evaluation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Human malaria parasites in continuous culture

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Purification of a reconstitutively active iron-sulfur protein (oxidation factor) from succinate . cytochrome c reductase complex of bovine heart mitochondria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Recent advances in lipid-based formulation technology.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Antimalarial drug discovery - the path towards eradication.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Optimization of endochin-like quinolones for antimalarial activity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Evaluation and lead optimization of anti-malarial acridones.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

A dye-based lymphocyte proliferation assay that permits multiple immunological analyses: mRNA, cytogenetic, apoptosis, and immunophenotyping studies

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018401

Physiological parameters in laboratory animals and humans

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24720377

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Naphthoquinone antimalarials; relative antirespiratory activities (Plasmodium lophurae)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24720377

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/24720377

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM500147K

1 reference

28 July 2017

1 reference

28 July 2017

1 reference