Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm (Q33600016)

28 July 2017

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title

Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm (English)

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28 July 2017

Krynetski EY

1

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28 July 2017

Evans WE

series ordinal

2

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28 July 2017

publication date

1 March 1999

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28 July 2017

published in

Pharmaceutical Research

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28 July 2017

volume

16

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28 July 2017

issue

3

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28 July 2017

page(s)

342-349

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Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?

28 July 2017

cites work

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12 December 2020

Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis

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12 December 2020

Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans

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12 December 2020

Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia

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12 December 2020

A tellurite-resistance genetic determinant from phytopathogenic pseudomonads encodes a thiopurine methyltransferase: evidence of a widely-conserved family of methyltransferases

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12 December 2020

Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

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12 December 2020

Beneficial effects of conversion from cyclosporin to azathioprine after kidney transplantation

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12 December 2020

Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms

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12 December 2020

Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA

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12 December 2020

Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase

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12 December 2020

Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C

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12 December 2020

Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes

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12 December 2020

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

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12 December 2020

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity

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12 December 2020

The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients

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12 December 2020

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

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12 December 2020

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

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12 December 2020

Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans.

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12 December 2020

Pharmacogenetics in cancer etiology and chemotherapy

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12 December 2020

Some statistical data on atypical cholinesterase of human serum

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12 December 2020

Pharmacogenetics of cancer therapy: getting personal

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12 December 2020

Thiol S-methylation in uremia: erythrocyte enzyme activities and plasma inhibitors

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12 December 2020

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

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12 December 2020

Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis

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12 December 2020

Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1

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12 December 2020

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms

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12 December 2020

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

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12 December 2020

Molecular genetics of the N-acetyltransferases.

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12 December 2020

Oral 6-mercaptopurine in childhood leukemia: parent drug pharmacokinetics and active metabolite concentrations

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12 December 2020

Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism

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12 December 2020

Thiopurine methyltransferase biochemical genetics: human lymphocyte activity

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12 December 2020

The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations

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12 December 2020

Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine

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12 December 2020

Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia

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12 December 2020

Thiopurine methyltransferase activity in American white subjects and black subjects

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12 December 2020

The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

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12 December 2020

Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity

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12 December 2020

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

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12 December 2020

Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT)

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12 December 2020

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.

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12 December 2020

Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia

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12 December 2020

Thiopurine Methyltransferase in Humans: Development and Tissue Distribution

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12 December 2020

Molecular mechanisms of genetic polymorphisms of drug metabolism

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12 December 2020

Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults

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12 December 2020

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

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12 December 2020

Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues

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12 December 2020

Polymorphism of the thiopurine S-methyltransferase gene in African-Americans

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12 December 2020

Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient.

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12 December 2020

Hypoxanthine-guanine phosphoribosyl-transferase in childhood leukemia: relation with immunophenotype, in vitro drug resistance and clinical prognosis

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12 December 2020

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

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12 December 2020

Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient

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12 December 2020

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia

1 reference

12 December 2020

Pharmacogenetics of human thiopurine methyltransferase: kidney-erythrocyte correlation and immunotitration studies

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12 December 2020

Identifiers

DOI

10.1023/A:1011909315614

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28 July 2017

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