Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis--the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation (Q33610773)

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English	Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis--the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation	scientific article

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scholarly article

1 reference

Europe PubMed Central

28 July 2017

Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis--the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation (English)

1 reference

Europe PubMed Central

28 July 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

M A Karsdal

1

1 reference

Europe PubMed Central

28 July 2017

I Byrjalsen

2

1 reference

Europe PubMed Central

28 July 2017

A C Bay-Jensen

3

1 reference

Europe PubMed Central

28 July 2017

K Henriksen

4

1 reference

Europe PubMed Central

28 July 2017

B J Riis

5

1 reference

Europe PubMed Central

28 July 2017

C Christiansen

6

1 reference

Europe PubMed Central

28 July 2017

publication date

17 June 2010

1 reference

Europe PubMed Central

28 July 2017

BMC Musculoskeletal Disorders

1 reference

Europe PubMed Central

28 July 2017

11

1 reference

Europe PubMed Central

28 July 2017

125

1 reference

Europe PubMed Central

28 July 2017

copyright license

Creative Commons Attribution 2.0 Generic

17 June 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

https://scigraph.springernature.com/pub.10.1186/1471-2474-11-125

0 references

The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development

1 reference

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28 July 2018

Influence of food intake on the bioavailability and efficacy of oral calcitonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: the effect of water and timing of meal intake on oral delivery of Salmon Calcitonin

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28 July 2018

Calcitonin: a drug of the past or for the future? Physiologic inhibition of bone resorption while sustaining osteoclast numbers improves bone quality

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28 July 2018

Should subchondral bone turnover be targeted when treating osteoarthritis?

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28 July 2018

Osteoclasts secrete non-bone derived signals that induce bone formation.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Strategies for the prevention and management of osteoarthritis of the hip and knee

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Osteoarthritis severity is sex dependent in a surgical mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Animal models of osteoarthritis: lessons learned while seeking the "Holy Grail".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Calcitonin is involved in cartilage homeostasis: is calcitonin a treatment for OA?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Osteoarthritis: epidemiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Rationale for the potential use of calcitonin in osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application

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28 July 2018

Inhibition of hydroxyapatite formation by osteopontin phosphopeptides

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Estrogens, cartilage, and osteoarthritis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

The role of bone metabolism in osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Molecular basis of osteoarthritis: biomechanical aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Is hormone replacement therapy protective for hand and knee osteoarthritis in women?: The Chingford Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Sex hormones and the risk of osteoarthritis in women: epidemiological evidence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Effect of calcitonin on glycosaminoglycan synthesis by embryo calf bone cells in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Endogenous sex steroid levels in women with generalised osteoarthritis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

28 July 2018

Marked diurnal variation in urinary excretion of pyridinium cross-links in premenopausal women

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28 July 2018

The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM).

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Classification of osteoarthritis biomarkers: a proposed approach.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Calcitonin affects both bone and cartilage: a dual action treatment for osteoarthritis?

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Biochemical markers for monitoring response to therapy: evidence for higher bone specificity by a novel marker compared with routine markers

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Evidence of altered bone turnover, vitamin D and calcium regulation with knee osteoarthritis in female twins.

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Osteoarthrosis of the knee in men and women in association with overweight, smoking, and hormone therapy

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis.

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Application of a new serum assay for type I collagen cross-linked N-telopeptides: assessment of diurnal changes in bone turnover with and without alendronate treatment

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2.

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Osteoarthritis: Is it a disease of cartilage or of bone?

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https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

The incidence and natural history of knee osteoarthritis in the elderly, the framingham osteoarthritis study

1 reference

https://api.crossref.org/works/10.1186%2F1471-2474-11-125

21 January 2018

Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization

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21 January 2018

Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

30 October 2018

Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

30 October 2018

Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits.

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30 October 2018

Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

30 October 2018

Serum sex hormones and severity of osteoarthritis of the hand.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902412

30 October 2018

A new marker for osteoarthritis: Cross-sectional and longitudinal approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of glycosaminoglycan synthesis by thyrocalcitonin preparations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Sensitivity of Isolated Osteoclasts to Morphological Transformation by Calcitonin*

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of human and salmon calcitonin on human articular chondrocytes cultivated in clusters

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of hormone therapy on risk of hip and knee joint replacement in the Women's Health Initiative

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcitonin induces podosome disassembly and detachment of osteoclasts by modulating Pyk2 and Src activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial fluid levels of tumor necrosis factor alpha and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Joint injury in young adults and risk for subsequent knee and hip osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early regional adaptation of periarticular bone mineral density after anterior cruciate ligament injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Periarticular cancellous bone changes following anterior cruciate ligament injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tibolone: prevention of bone loss in late postmenopausal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcitonin inhibits phospholipase A2 and collagenase activity of human osteoarthritic chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pharmacokinetic and pharmacodynamic comparison of synthetic and recombinant oral salmon calcitonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum CrossLaps One Step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring of Alendronate Treatment and Prediction of Effect on Bone Mass by Biochemical Markers in the Early Postmenopausal Intervention Cohort Study1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphometric changes in the epiphyseal plate of the growing and young adult male rat after long-term salmon calcitonin administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20565725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-2474-11-125

1 reference

Europe PubMed Central

28 July 2017

Dimensions Publication ID

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2474-11-125

9 September 2019

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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