Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel. (Q33614661)

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7 December 2019

title

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel (English)

1 reference

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7 December 2019

1 reference

1 reference

5

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7 December 2019

author name string

T C Chou

1

1 reference

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7 December 2019

X G Zhang

2

1 reference

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7 December 2019

C R Harris

3

1 reference

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7 December 2019

S D Kuduk

4

1 reference

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7 December 2019

K A Savin

6

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7 December 2019

J R Bertino

7

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7 December 2019

S J Danishefsky

8

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7 December 2019

language of work or name

English

0 references

publication date

1 December 1998

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

7 December 2019

published in

1 reference

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7 December 2019

volume

95

1 reference

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7 December 2019

issue

26

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7 December 2019

page(s)

15798-15802

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Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.

7 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Synthesis of epothilones A and B in solid and solution phase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Clinical toxicities encountered with paclitaxel (Taxol).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

New colorimetric cytotoxicity assay for anticancer-drug screening

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Taxol: a review of its preclinical in vivo antitumor activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Promotion of microtubule assembly in vitro by taxol

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28124

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

21 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

Total Synthesis of(–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

Total Synthesis of(–)-Epothilone A

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

Tumor-killer made; how does it work?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

Total Synthesis of Epothilone A: The Olefin Metathesis Approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

Total Synthesis of(−)-Epothilone A

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

Current results of the screening program at the Division of Cancer Treatment, National Cancer Institute

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

Chemical Biology of Epothilones

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15798

21 January 2018

Identifiers

DOI

10.1073/PNAS.95.26.15798

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9861050%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

0 references

1 reference

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7 December 2019

1 reference