Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin (Q33614759)

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English	Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin	scientific article

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12 January 2020

Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin (English)

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12 January 2020

Grover P. Miller

1

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12 January 2020

2

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12 January 2020

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Agnieszka K Zielinska

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12 January 2020

Anna Mazur

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12 January 2020

Stacie M Bratton

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12 January 2020

Anna Gallus-Zawada

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12 January 2020

Moshe Finel

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12 January 2020

Jeffery H Moran

8

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12 January 2020

Anna Radominska-Pandya

9

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12 January 2020

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25 August 2008

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12 January 2020

Drug Metabolism and Disposition

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12 January 2020

36

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12 January 2020

11

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12 January 2020

2211-2218

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12 January 2020

Glucuronidation of monohydroxylated warfarin metabolites by human liver microsomes and human recombinant UDP-glucuronosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812427

21 June 2018

CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812427

21 June 2018

Phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812427

21 June 2018

Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer

1 reference

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21 June 2018

Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812427

21 June 2018

Human P450 metabolism of warfarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812427

21 June 2018

Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase

1 reference

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21 June 2018

Phase II metabolism of warfarin in primary culture of adult rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812427

21 June 2018

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1 reference

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21 June 2018

Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812427

30 October 2018

Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812427

30 October 2018

Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy

1 reference

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30 October 2018

Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/18725508

12 December 2020

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10.1124/DMD.108.022863

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12 January 2020

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12 January 2020

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