Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation (Q33616502)

28 July 2017

Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation (English)

1 reference

28 July 2017

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4

Jan M van Deursen

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28 July 2017

Janine H van Ree

1

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28 July 2017

Karthik B Jeganathan

series ordinal

2

1 reference

28 July 2017

Liviu Malureanu

series ordinal

3

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28 July 2017

language of work or name

English

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publication date

1 January 2010

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28 July 2017

18

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inferred from page(s)

published in

Journal of Cell Biology

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28 July 2017

188

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28 July 2017

1

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28 July 2017

83-100

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describes a project that uses

28 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2812857/fullTextXML

inferred from PubMed Central ID database lookup

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Identification of a physiological E2 module for the human anaphase-promoting complex

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UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

21 June 2018

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Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.

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Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells

21 June 2018

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Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice

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A mechanism linking extra centrosomes to chromosomal instability

21 June 2018

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Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex

21 June 2018

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BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase

21 June 2018

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Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding

21 June 2018

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Genome stability is ensured by temporal control of kinetochore-microtubule dynamics

21 June 2018

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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

21 June 2018

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When 2+2=5: the origins and fates of aneuploid and tetraploid cells

21 June 2018

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Whole chromosome instability and cancer: a complex relationship

21 June 2018

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21 June 2018

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Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha

21 June 2018

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Examining the link between chromosomal instability and aneuploidy in human cells

21 June 2018

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Fluorescence in situ Hybridization (FISH).

21 June 2018

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Oncogenes and tumour suppressors take on centrosomes

21 June 2018

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Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

21 June 2018

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UbcH10 is overexpressed in malignant breast carcinomas

21 June 2018

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Bub1 maintains centromeric cohesion by activation of the spindle checkpoint

21 June 2018

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Finishing mitosis, one step at a time.

21 June 2018

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Cdc20: a WD40 activator for a cell cycle degradation machine

21 June 2018

1 reference

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Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

21 June 2018

1 reference

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The spindle-assembly checkpoint in space and time

21 June 2018

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UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas

21 June 2018

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The anaphase promoting complex/cyclosome: a machine designed to destroy

21 June 2018

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Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

21 June 2018

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Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

21 June 2018

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UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas

21 June 2018

1 reference

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The structure and function of SMC and kleisin complexes

21 June 2018

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Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.

21 June 2018

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Timing and checkpoints in the regulation of mitotic progression

21 June 2018

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Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin

21 June 2018

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Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity

21 June 2018

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Aurora B regulates MCAK at the mitotic centromere

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Centrosome aberrations: cause or consequence of cancer progression?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex/cyclosome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Testis-specific murine centrin, Cetn1: genomic characterization and evidence for retroposition of a gene encoding a centrosome protein.

21 June 2018

1 reference

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CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity

21 June 2018

1 reference

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Cre-mediated gene deletion in the mammary gland

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

UbcH10 has a rate-limiting role in G1 phase but might not act in the spindle checkpoint or as part of an autonomous oscillator.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Breaking the ties that bind centriole numbers

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Cre-conditional expression of constitutively active Notch1 in transgenic mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Cell biology: aneuploidy and cancer.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Aneuploidy acts both oncogenically and as a tumor suppressor

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812857

Gene targeting in mouse embryonic stem cells

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20065091

12 December 2020

inferred from PubMed ID database lookup

Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20065091

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1083/JCB.200906147

1 reference

28 July 2017

1 reference

28 July 2017

1 reference