Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization (Q33620516)

28 July 2017

title

Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization (English)

1 reference

28 July 2017

Gavin J Williams

1

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28 July 2017

Randal D Goff

series ordinal

2

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28 July 2017

Changsheng Zhang

series ordinal

3

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28 July 2017

Jon S Thorson

series ordinal

4

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28 July 2017

publication date

1 April 2008

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28 July 2017

published in

Chemistry and Biology

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28 July 2017

volume

15

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28 July 2017

issue

4

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28 July 2017

page(s)

393-401

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Natural product glycosyltransferases: properties and applications

28 July 2017

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21 June 2018

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21 June 2018

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Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.

21 June 2018

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21 June 2018

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21 June 2018

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30 October 2018

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30 October 2018

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30 October 2018

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30 October 2018

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30 October 2018

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30 October 2018

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Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

30 October 2018

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12 December 2020

Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization

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12 December 2020

Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses

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Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin

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10.1016/J.CHEMBIOL.2008.02.017

Identifiers

DOI

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28 July 2017

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28 July 2017

1 reference