The human glucocorticoid receptor: molecular basis of biologic function (Q33620765)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19818358%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

review article

1 reference

title

The human glucocorticoid receptor: molecular basis of biologic function (English)

1 reference

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9 February 2020

author

Evangelia Charmandari

5

1 reference

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9 February 2020

4

George P Chrousos

1 reference

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9 February 2020

author name string

Nicolas C Nicolaides

1

1 reference

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9 February 2020

Zoi Galata

2

1 reference

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9 February 2020

Tomoshige Kino

3

1 reference

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9 February 2020

publication date

7 October 2009

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9 February 2020

1 reference

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9 February 2020

volume

75

1 reference

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9 February 2020

issue

1

1 reference

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9 February 2020

page(s)

1-12

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Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity

9 February 2020

cites work

1 reference

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Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles.

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Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder

21 June 2018

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Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress

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Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification.

21 June 2018

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Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

21 June 2018

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Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function.

21 June 2018

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Intracellular glucocorticoid signaling: a formerly simple system turns stochastic

21 June 2018

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Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes.

21 June 2018

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The human glucocorticoid receptor: one gene, multiple proteins and diverse responses

21 June 2018

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Rush hour at the promoter: how the ubiquitin-proteasome pathway polices the traffic flow of nuclear receptor-dependent transcription

21 June 2018

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Linking the ubiquitin-proteasome pathway to chromatin remodeling/modification by nuclear receptors.

21 June 2018

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p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211.

21 June 2018

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A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity

21 June 2018

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Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9.

21 June 2018

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Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms

21 June 2018

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Modulation of glucocorticoid receptor function via phosphorylation.

21 June 2018

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Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission, and clinical phenotype.

21 June 2018

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Physical and functional association of RNA polymerase II and the proteasome

21 June 2018

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Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition

21 June 2018

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Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy

21 June 2018

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Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

21 June 2018

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21 June 2018

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The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism

21 June 2018

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Molecular mechanisms of glucocorticoid action and resistance

21 June 2018

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21 June 2018

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Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition

21 June 2018

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Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking.

21 June 2018

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Female pseudohermaphroditism caused by a novel homozygous missense mutation of the GR gene

21 June 2018

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Combinatorial control of gene expression by nuclear receptors and coregulators

21 June 2018

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A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins

21 June 2018

1 reference

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Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

21 June 2018

1 reference

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Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking

21 June 2018

1 reference

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Gene family evolution and homology: genomics meets phylogenetics

21 June 2018

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Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids

21 June 2018

1 reference

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AP-1--glucocorticoid receptor crosstalk taken to a higher level

21 June 2018

1 reference

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Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes

21 June 2018

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Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions

21 June 2018

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Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding

21 June 2018

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The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action

21 June 2018

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Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways

21 June 2018

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Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.

21 June 2018

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Nuclear receptor coregulators: cellular and molecular biology

21 June 2018

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Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor

21 June 2018

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Transcriptional cross-talk, the second mode of steroid hormone receptor action.

21 June 2018

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DNA binding of the glucocorticoid receptor is not essential for survival

21 June 2018

1 reference

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Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains

21 June 2018

1 reference

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Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase

21 June 2018

1 reference

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A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo.

21 June 2018

1 reference

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A signature motif in transcriptional co-activators mediates binding to nuclear receptors

21 June 2018

1 reference

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GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors

21 June 2018

1 reference

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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

21 June 2018

1 reference

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Interaction of steroid hormone receptors with the transcription initiation complex

21 June 2018

1 reference

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Functional interactions between Stat5 and the glucocorticoid receptor

21 June 2018

1 reference

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Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation.

21 June 2018

1 reference

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Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination

21 June 2018

1 reference

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Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids

21 June 2018

1 reference

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Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids

21 June 2018

1 reference

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Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor

21 June 2018

1 reference

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Clinical aspects of glucocorticoid sensitivity

21 June 2018

1 reference

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GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors

21 June 2018

1 reference

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Kinetics of glucocorticoid receptor phosphorylation in intact cells. Evidence for hormone-induced hyperphosphorylation after activation and recycling of hyperphosphorylated receptors

21 June 2018

1 reference

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The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor

21 June 2018

1 reference

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The constitution of a progesterone response element

21 June 2018

1 reference

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Syndromes of glucocorticoid resistance

21 June 2018

1 reference

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A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

21 June 2018

1 reference

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Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors

21 June 2018

1 reference

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A mutation of the glucocorticoid receptor in primary cortisol resistance

21 June 2018

1 reference

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Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

21 June 2018

1 reference

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Primary cortisol resistance in man. A glucocorticoid receptor-mediated disease

21 June 2018

1 reference

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Pituitary-adrenal function in the squirrel monkey.

21 June 2018

1 reference

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Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

21 June 2018

1 reference

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Primary structure and expression of a functional human glucocorticoid receptor cDNA

21 June 2018

1 reference

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Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

21 June 2018

1 reference

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Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

21 June 2018

1 reference

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Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance

21 June 2018

1 reference

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A TthIII1 polymorphism on the 5′ flanking region of the glucocorticoid receptor gene (GRL)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Spontaneous Hypercortisolism without Cushing's Syndrome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

The N363S polymorphism in the glucocorticoid receptor gene is associated with overweight in subjects with type 2 diabetes mellitus.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Association of coronary artery disease with glucocorticoid receptor N363S variant

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Coordinate regulation of transcription and splicing by steroid receptor coregulators

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Potentiation of glucocorticoid receptor transcriptional activity by sumoylation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Tissue-specific glucocorticoid resistance-hypersensitivity syndromes: multifactorial states of clinical importance.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Protein tyrosine kinase cDNAs from amphioxus, hagfish, and lamprey: isoform duplications around the divergence of cyclostomes and gnathostomes.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). Species-specific differences between human and rat glucocorticoid receptor signaling as revealed through GSK-3 phosphoryl

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813911

Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathway

30 October 2018

1 reference

12 December 2020

Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant

1 reference

12 December 2020

Intracellular localization of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localization

1 reference

12 December 2020

v-mos oncoproteins affect the nuclear retention and reutilization of glucocorticoid receptors

1 reference

12 December 2020

Glucocorticoid Action Networks—An Introduction to Systems Biology

1 reference

12 December 2020

The glucocorticoid receptor gene, longevity, and the complex disorders of Western societies

1 reference

12 December 2020

Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus

1 reference

12 December 2020

Functional Characterization of the Natural Human Glucocorticoid Receptor (hGR) Mutants hGRαR477H and hGRαG679S Associated with Generalized Glucocorticoid Resistance

1 reference

12 December 2020

Association of glucocorticoid receptor polymorphism A3669G in exon 9beta with reduced central adiposity in women

1 reference

12 December 2020

An active nuclear retention signal in the glucocorticoid receptor functions as a strong inducer of transcriptional activation

1 reference

12 December 2020

10.1016/J.STEROIDS.2009.09.002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19818358%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19818358%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference