Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase (Q33630320)

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English	Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

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1 reference

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author name string

M F Belcourt

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

W F Hodnick

2

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

S Rockwell

3

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

A C Sartorelli

4

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Europe PubMed Central

PubMed publication ID

28 July 2017

language of work or name

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publication date

1 January 1996

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Europe PubMed Central

PubMed publication ID

28 July 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

28 July 2017

93

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Europe PubMed Central

PubMed publication ID

28 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

456-460

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Europe PubMed Central

PubMed publication ID

28 July 2017

An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study

1 reference

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21 June 2018

Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Mechanism of differential sensitivity of human bladder cancer cells to mitomycin C and its analogue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Characterization of a human bladder cancer cell line selected for resistance to mitomycin C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Mitomycin C: a prototype bioreductive agent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

The hypoxic tumor cell: a target for selective cancer chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

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21 June 2018

Glutathione S-transferases. The first enzymatic step in mercapturic acid formation

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21 June 2018

Interactions of mitomycin C with mammalian DNA detected by alkaline elution

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Measurement of protein using bicinchoninic acid

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Preclinical studies of porfiromycin as an adjunct to radiotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Therapeutic attack of hypoxic cells of solid tumors: presidential address

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Effects of glutathione and ethylxanthate on mitomycin C activation by isolated rat hepatic or EMT6 mouse mammary tumor nuclei.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Activation of mitomycin C by NADPH:cytochrome P-450 reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Effect of deficiencies in DNA repair on the toxicity of mitomycin C and porfiromycin to CHO cells under aerobic and hypoxic conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Diversity of penetration of anti-cancer agents into solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Cytotoxicity and DNA crosslinks produced by mitomycin analogs in aerobic and hypoxic EMT6 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

In vivo-in vitro tumor systems: new models for studing the response of tumours to therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Reduction of anthracycline glycoside by NADPH--cytochrome P-450 reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

21 June 2018

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

30 October 2018

The regulation of rat liver xanthine oxidase. Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40257

30 October 2018

Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanism of the cytotoxic action of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomized clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA alkylation by enzyme-activated mitomycin C

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One-electron-transfer reactions in biochemical systems. 3. One-electron reduction of quinones by microsomal flavin enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic activation of mitomycin C by liver microsomes and nuclei

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8552660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.93.1.456

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

1996PNAS...93..456B

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

ResearchGate publication ID

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