Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold (Q33646218)

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English	Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold	scientific article

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scholarly article

1 reference

Europe PubMed Central

28 July 2017

Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold (English)

1 reference

Europe PubMed Central

28 July 2017

1 reference

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author name string

J Sharon

1

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Europe PubMed Central

28 July 2017

language of work or name

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publication date

1 June 1990

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Europe PubMed Central

28 July 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

28 July 2017

87

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Europe PubMed Central

28 July 2017

12

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Europe PubMed Central

28 July 2017

4814-4817

1 reference

Europe PubMed Central

28 July 2017

Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Amino acid sequence diversity within the family of antibodies bearing the major antiarsonate cross-reactive idiotype of the A strain mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1 reference

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21 June 2018

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1 reference

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21 June 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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21 June 2018

Rate of somatic mutation in immunoglobulin production by mouse myeloma cells

1 reference

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21 June 2018

Cell Selection by Antigen in the Immune Response

1 reference

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21 June 2018

Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. II. Evidence for separate stimulatory and inhibitory cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains

1 reference

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21 June 2018

Somatic evolution of variable region structures during an immune response

1 reference

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21 June 2018

Mutation drift and repertoire shift in the maturation of the immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Evolution of antibody variable region structure during the immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Stepwise intraclonal maturation of antibody affinity through somatic hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions

1 reference

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21 June 2018

Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Inhibition of restriction endonuclease Nci I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Crystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

21 June 2018

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

1 reference

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21 June 2018

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

30 October 2018

The genetic basis of antibody production: a single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

30 October 2018

Expression of a Bacterial Gene in Mammalian Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

30 October 2018

Variability in the Lambda Light Chain Sequences of Mouse Antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=54208

30 October 2018

32 Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/2352950

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a VHCκ chimaeric protein in mouse myeloma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/2352950

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germ-line sequence of the DH segment employed in Ars-A antibodies: implications for the generation of junctional diversity

1 reference

https://pubmed.ncbi.nlm.nih.gov/2352950

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of an antibody with enhanced affinity and specificity for its antigen by protein engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/2352950

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetic basis of antibody production: The dominant anti-arsonate idiotype response of the strain a mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/2352950

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinity analysis of idiotype-positive and idiotype-negative Ars-binding hybridoma proteins and Ars-immune sera

1 reference

https://pubmed.ncbi.nlm.nih.gov/2352950

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The complete amino acid sequence of the light chain variable region of two monoclonal anti-p-azobenzene-arsonate antibodies bearing the cross-reactive idiotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/2352950

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degree of heterogeneity of binding specificities of antibodies to the phenylarsonate group that share a common idiotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/2352950

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.87.12.4814

1 reference

Europe PubMed Central

28 July 2017

1990PNAS...87.4814S

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1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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