Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries. (Q33647302)

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English	Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.	scientific article

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9 February 2020

Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries (English)

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9 February 2020

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9 February 2020

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9 February 2020

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Martin Hintersteiner

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9 February 2020

Géza Ambrus

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9 February 2020

Janna Bednenko

3

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9 February 2020

Mario Schmied

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9 February 2020

Nicole-Claudia Meisner

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9 February 2020

Hubert Gstach

7

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9 February 2020

Jan-Marcus Seifert

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9 February 2020

Eric L Singer

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9 February 2020

Larry Gerace

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9 February 2020

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1 October 2010

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9 February 2020

ACS Chemical Biology

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9 February 2020

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9 February 2020

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9 February 2020

967-979

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9 February 2020

Single bead labeling method for combining confocal fluorescence on-bead screening and solution validation of tagged one-bead one-compound libraries

1 reference

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28 July 2018

Confocal nanoscanning, bead picking (CONA): PickoScreen microscopes for automated and quantitative screening of one-bead one-compound libraries

1 reference

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Terminal adenosyl transferase activity of posttranscriptional regulator HuR revealed by confocal on-bead screening

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Reconstitution of nuclear import in permeabilized cells

1 reference

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Design of peptide inhibitors for the importin alpha/beta nuclear import pathway by activity-based profiling

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Molecular basis for the recognition of snurportin 1 by importin beta

1 reference

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28 July 2018

Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport

1 reference

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High-content classification of nucleocytoplasmic import or export inhibitors

1 reference

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Structural biology of nucleocytoplasmic transport

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Intracellular localization and nucleocytoplasmic trafficking of steroid receptors: an overview

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Structural basis for nuclear import complex dissociation by RanGTP

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The chemical hunt for the identification of drugable targets.

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Importin beta contains a COOH-terminal nucleoporin binding region important for nuclear transport

1 reference

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Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs

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Nucleocytoplasmic transport: navigating the channel

1 reference

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Nuclear transport as a target for cell growth

1 reference

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28 July 2018

Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import

1 reference

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The direction of transport through the nuclear pore can be inverted

1 reference

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A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956136

28 July 2018

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

1 reference

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Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro

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Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

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Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

1 reference

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A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus

1 reference

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Analysis of Ran/TC4 function in nuclear protein import

1 reference

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Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor

1 reference

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Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope

1 reference

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1 reference

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Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956136

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Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action

1 reference

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Single-bead, single-molecule, single-cell fluorescence: technologies for drug screening and target validation

1 reference

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30 October 2018

Molecular mechanism of the nuclear protein import cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956136

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1 reference

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30 October 2018

Importins and exportins: how to get in and out of the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956136

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20677820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/CB100094K

1 reference

Europe PubMed Central

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9 February 2020

PMC publication ID

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9 February 2020

PubMed publication ID

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9 February 2020

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