Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies (Q33651025)

28 July 2017

title

Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies (English)

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28 July 2017

1 reference

Peng Hsiao

1

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28 July 2017

Jashvant D Unadkat

series ordinal

2

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28 July 2017

language of work or name

English

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publication date

7 January 2014

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28 July 2017

published in

Molecular Pharmaceutics

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28 July 2017

volume

11

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28 July 2017

issue

2

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28 July 2017

page(s)

436-444

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Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.

28 July 2017

cites work

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Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data

21 June 2018

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Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity

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21 June 2018

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P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

21 June 2018

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21 June 2018

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21 June 2018

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 June 2018

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21 June 2018

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30 October 2018

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In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier

30 October 2018

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Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid

30 October 2018

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Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

30 October 2018

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Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier

30 October 2018

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Dependence of nelfinavir brain uptake on dose and tissue concentrations of the selective P-glycoprotein inhibitor zosuquidar in rats

30 October 2018

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Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

30 October 2018

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Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm.

30 October 2018

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Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates

30 October 2018

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HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2).

30 October 2018

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Intravenous verapamil kinetics in rats: marked arteriovenous concentration difference and comparison with humans.

30 October 2018

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Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

30 October 2018

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12 December 2020

Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes

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12 December 2020

Communication between multiple drug binding sites on P-glycoprotein

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12 December 2020

Human in vivo competitive inhibition of P450 substrates: increased plasma concentrations as a function of hepatic extraction ratio and percent inhibition

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12 December 2020

Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis

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12 December 2020

Identifiers

DOI

10.1021/MP400396K

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28 July 2017

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28 July 2017

1 reference