Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging (Q33661948)

28 July 2017

title

Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging (English)

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28 July 2017

6

John V Frangioni

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28 July 2017

Kelly Davis Orcutt

1

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28 July 2017

Adrian L Slusarczyk

2

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28 July 2017

Maryelise Cieslewicz

3

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28 July 2017

Benjamin Ruiz-Yi

4

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28 July 2017

Kumar R Bhushan

5

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28 July 2017

K Dane Wittrup

7

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28 July 2017

publication date

27 October 2010

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Nuclear Medicine and Biology

28 July 2017

published in

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28 July 2017

volume

38

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28 July 2017

issue

2

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28 July 2017

page(s)

223-233

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A modular IgG-scFv bispecific antibody topology

28 July 2017

cites work

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21 June 2018

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In vivo biodistribution, PET imaging, and tumor accumulation of 86Y- and 111In-antimindin/RG-1, engineered antibody fragments in LNCaP tumor-bearing nude mice.

21 June 2018

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Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling

21 June 2018

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Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability.

21 June 2018

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Cancer Imaging and Therapy with Bispecific Antibody Pretargeting

21 June 2018

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Nephrogenic systemic fibrosis risk: is there a difference between gadolinium-based contrast agents?

21 June 2018

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Production of multimeric prostate-specific membrane antigen small-molecule radiotracers using a solid-phase 99mTc preloading strategy

21 June 2018

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Isolating and engineering human antibodies using yeast surface display

21 June 2018

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Comparative biodistributions of pretargeted radioimmunoconjugates targeting CD20, CD22, and DR molecules on human B-cell lymphomas

21 June 2018

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An HPLC/mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: prostate-specific membrane antigen small molecule derivatives

21 June 2018

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Antibodies with infinite affinity: origins and applications

21 June 2018

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Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice

21 June 2018

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Successful radiotherapy of tumor in pretargeted mice by 188Re-radiolabeled phosphorodiamidate morpholino oligomer, a synthetic DNA analogue

21 June 2018

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Recombinant approaches to IgG-like bispecific antibodies

21 June 2018

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Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37 degrees C.

21 June 2018

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Crystal structures of two complexes of the rare-earth-DOTA-binding antibody 2D12.5: ligand generality from a chiral system

21 June 2018

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Conformational characterization of lanthanide(III)-DOTA complexes by ab initio investigation in vacuo and in aqueous solution.

21 June 2018

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Anti-HLA-DR/anti-DOTA diabody construction in a modular gene design platform: bispecific antibodies for pretargeted radioimmunotherapy

21 June 2018

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Conformational and Coordination Equilibria on DOTA Complexes of Lanthanide Metal Ions in Aqueous Solution Studied by (1)H-NMR Spectroscopy

21 June 2018

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Phase II trial of yttrium-90-DOTA-biotin pretargeted by NR-LU-10 antibody/streptavidin in patients with metastatic colon cancer

21 June 2018

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Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity

21 June 2018

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Radioimmunodetection of medullary thyroid carcinoma using indium-111 bivalent hapten and anti-CEA x anti-DTPA-indium bispecific antibody.

21 June 2018

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How the anti-(metal chelate) antibody CHA255 is specific for the metal ion of its antigen: X-ray structures for two Fab'/hapten complexes with different metals in the chelate

21 June 2018

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Gd-DOTA. Pharmacokinetics and tolerability after intravenous injection into healthy volunteers.

21 June 2018

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Bifunctional antibody: a binary radiopharmaceutical delivery system for imaging colorectal carcinoma

21 June 2018

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Theoretic criteria for antibody penetration into solid tumors and micrometastases.

21 June 2018

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Tunable pharmacokinetics: modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment

30 October 2018

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Pretargeted radioimmunotherapy with a single-chain antibody/streptavidin construct and radiolabeled DOTA-biotin: strategies for reduction of the renal dose

30 October 2018

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Converting weak binders into infinite binders

30 October 2018

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Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody

30 October 2018

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Complexing mechanism of the lanthanide cations Eu3+, Gd3+, and Tb3+ with 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (dota)-characterization of three successive complexing phases: study of the thermodynamic and structural propert

30 October 2018

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Synthesis, characterization, and X-ray crystal structure of In(DOTA-AA) (AA = p-aminoanilide): a model for 111In-labeled DOTA-biomolecule conjugates

30 October 2018

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Preparation of diamines by lithiation-substitution of imidazolidines and pyrimidines

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033581

A rare earth-DOTA-binding antibody: probe properties and binding affinity across the lanthanide series

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033581

A streptavidin-biotin binding system that minimizes blocking by endogenous biotin.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033581

Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033581

Astatine-211-labeled biotin conjugates resistant to biotinidase for use in pretargeted radioimmunotherapy.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033581

The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033581

Pharmacokinetics of pretargeted monoclonal antibody 2D12.5 and 88Y-Janus-2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecanetetraacetic acid (DOTA) in BALB/c mice with KHJJ mouse adenocarcinoma: a model for 90Y radioimmunotherapy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033581

Targeting, toxicity, and efficacy of 2-step, pretargeted radioimmunotherapy using a chimeric bispecific antibody and 131I-labeled bivalent hapten in a phase I optimization clinical trial

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033581

Tumor pretargeting for radioimmunodetection and radioimmunotherapy

30 October 2018

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12 December 2020

Absorbed fractions for electrons and beta particles in spheres of various sizes

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12 December 2020

Biodistribution and dosimetry of pretargeted monoclonal antibody 2D12.5 and Y-Janus-DOTA in BALB/c mice with KHJJ mouse adenocarcinoma

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12 December 2020

Bivalent hapten-bearing peptides designed for iodine-131 pretargeted radioimmunotherapy

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12 December 2020

A universal pretargeting system for cancer detection and therapy using bispecific antibody

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12 December 2020

Antibody-based sensors for heavy metal ions

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12 December 2020

In vitro and in vivo targeting of radiolabeled monovalent and divalent haptens with dual specificity monoclonal antibody conjugates: enhanced divalent hapten affinity for cell-bound antibody conjugate

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12 December 2020

Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies

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12 December 2020

Biodistribution and histological localization of anti-human colon cancer monoclonal antibody (MAb) 1A3: the influence of administered MAb dose on tumor uptake

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12 December 2020

10.1016/J.NUCMEDBIO.2010.08.013

Identifiers

DOI

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28 July 2017

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28 July 2017

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