Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies (Q33662463)

28 July 2017

title

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies (English)

1 reference

28 July 2017

Victor Kenyon

10

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Adam Yasgar

object named as

Adam Yasgar

6

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Ajit Jadhav

object named as

Ajit Jadhav

11

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Anton Simeonov

12

object named as

Anton Simeonov

1 reference

28 July 2017

7

Steve Perry

1 reference

28 July 2017

Ganesha Rai

1

1 reference

28 July 2017

Netra Joshi

2

1 reference

28 July 2017

Joo Eun Jung

3

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28 July 2017

Yu Liu

4

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28 July 2017

Lena Schultz

5

1 reference

28 July 2017

Giovanni Diaz

8

1 reference

28 July 2017

Qiangli Zhang

9

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28 July 2017

Eng H Lo

13

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28 July 2017

Klaus van Leyen

14

1 reference

28 July 2017

David J Maloney

15

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28 July 2017

Theodore R Holman

16

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28 July 2017

language of work or name

English

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publication date

13 May 2014

1 reference

Journal of Medicinal Chemistry

28 July 2017

published in

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28 July 2017

volume

57

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28 July 2017

issue

10

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28 July 2017

page(s)

4035-4048

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12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia

28 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

21 June 2018

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12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet

21 June 2018

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21 June 2018

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Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia

21 June 2018

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Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation

21 June 2018

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21 June 2018

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A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism

21 June 2018

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Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis

21 June 2018

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21 June 2018

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Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.

21 June 2018

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GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma

21 June 2018

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21 June 2018

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Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase

21 June 2018

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12-Lipoxygenase products increase monocyte:endothelial interactions

21 June 2018

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Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

21 June 2018

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Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells

21 June 2018

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Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice

21 June 2018

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Potential anti-inflammatory effects of 5-lipoxygenase inhibition--exemplified by the leukotriene synthesis inhibitor BAY X 1005.

21 June 2018

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21 June 2018

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21 June 2018

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A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

21 June 2018

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Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties

21 June 2018

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21 June 2018

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The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products

21 June 2018

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21 June 2018

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Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis

21 June 2018

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Oxidative stress induces apoptosis in embryonic cortical neurons.

21 June 2018

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Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis

21 June 2018

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Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

21 June 2018

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A model for compounds active against human rhinovirus-14 based on X-ray crystallography data

21 June 2018

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Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

21 June 2018

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Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment.

30 October 2018

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Baicalein and 12/15-lipoxygenase in the ischemic brain

30 October 2018

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Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones.

30 October 2018

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Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment

30 October 2018

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Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase

30 October 2018

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Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

30 October 2018

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Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase

30 October 2018

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Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases

30 October 2018

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In vitro model of oxidative stress in cortical neurons

30 October 2018

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30 October 2018

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Probing sponge-derived terpenoids for human 15-lipoxygenase inhibitors

30 October 2018

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The role of 12-lipoxygenase in pancreatic -cells (Review).

30 October 2018

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Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling

30 October 2018

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12 December 2020

Inhibitors of 15-lipoxygenase from orange peel

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12 December 2020

A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors

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12 December 2020

Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis

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12 December 2020

Identifiers

DOI

10.1021/JM401915R

1 reference

28 July 2017

1 reference

28 July 2017

1 reference