Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands (Q33667482)

28 July 2017

title

Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands (English)

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28 July 2017

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28 July 2017

4

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28 July 2017

David D Boehr

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28 July 2017

Dan McElheny

series ordinal

2

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28 July 2017

language of work or name

English

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publication date

8 January 2010

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Proceedings of the National Academy of Sciences of the United States of America

28 July 2017

published in

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28 July 2017

volume

107

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28 July 2017

issue

4

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28 July 2017

page(s)

1373-1378

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Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis

28 July 2017

cites work

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The dynamic energy landscape of dihydrofolate reductase catalysis

14 July 2018

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Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase

14 July 2018

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Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

14 July 2018

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Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

14 July 2018

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Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4

14 July 2018

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Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications

14 July 2018

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Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

14 July 2018

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Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis

14 July 2018

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The Energy Landscapes and Motions of Proteins

14 July 2018

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14 July 2018

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14 July 2018

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Dynamics of the dihydrofolate reductase-folate complex: catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Allosteric communication in dihydrofolate reductase: signaling network and pathways for closed to occluded transition and back

21 January 2018

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Dynamics of ATP-binding cassette contribute to allosteric control, nucleotide binding and energy transduction in ABC transporters

21 January 2018

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Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH

21 January 2018

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30 October 2018

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0914163107

1 reference

28 July 2017

0 references

1 reference

28 July 2017

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