A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis. (Q33667575)

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16 January 2020

title

A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis (English)

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16 January 2020

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1

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16 January 2020

Artur Llobet

3

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16 January 2020

Francisca Rubio-Moscardó

4

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Noèlia Fernàndez-Castillo

16 January 2020

7

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16 January 2020

Miguel A Valverde

9

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16 January 2020

Bru Cormand

11

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José M Fernández-Fernández

16 January 2020

12

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16 January 2020

author name string

Ester Cuenca-León

2

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16 January 2020

Cristina Plata

5

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16 January 2020

Oriel Carreño

6

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16 January 2020

Roser Corominas

8

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16 January 2020

Alfons Macaya

10

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16 January 2020

language of work or name

English

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publication date

8 January 2010

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Proceedings of the National Academy of Sciences of the United States of America

16 January 2020

published in

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volume

107

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16 January 2020

issue

4

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16 January 2020

page(s)

1672-1677

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The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition

16 January 2020

cites work

1 reference

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Multiple roles of calcium ions in the regulation of neurotransmitter release

14 July 2018

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Familial hemiplegic migraine

14 July 2018

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The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release

14 July 2018

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Sporadic and familial hemiplegic migraine: diagnosis and treatment

14 July 2018

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Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures

14 July 2018

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Specific kinetic alterations of human CaV2.1 calcium channels produced by mutation S218L causing familial hemiplegic migraine and delayed cerebral edema and coma after minor head trauma

14 July 2018

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Deletion of the synaptic protein interaction site of the N-type (CaV2.2) calcium channel inhibits secretion in mouse pheochromocytoma cells

14 July 2018

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Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects

14 July 2018

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A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression

14 July 2018

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14 July 2018

The genetics of migraine

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Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage-dependent inactivation of HVA calcium channels.

14 July 2018

1 reference

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The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel

14 July 2018

1 reference

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Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating

14 July 2018

1 reference

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Structure and regulation of voltage-gated Ca2+ channels

14 July 2018

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Syntaxin modulation of calcium channels in cortical synaptosomes as revealed by botulinum toxin C1.

14 July 2018

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Three new familial hemiplegic migraine mutants affect P/Q-type Ca(2+) channel kinetics

14 July 2018

1 reference

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Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine

14 July 2018

1 reference

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Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse.

14 July 2018

1 reference

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Familial hemiplegic migraine mutations change alpha1A Ca2+ channel kinetics

14 July 2018

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Ca2+- and voltage-dependent inactivation of Ca2+ channels in nerve terminals of the neurohypophysis.

14 July 2018

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Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4

14 July 2018

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Pathophysiology of the migraine aura. The spreading depression theory

14 July 2018

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Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model

14 July 2018

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Structures and functions of calcium channel beta subunits

21 January 2018

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Functional impact of syntaxin on gating of N-type and Q-type calcium channels

21 January 2018

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Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins.

21 January 2018

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Early-onset progressive ataxia associated with the first CACNA1A mutation identified within the I-II loop

21 January 2018

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Repositioning of charged I-II loop amino acid residues within the electric field by beta subunit as a novel working hypothesis for the control of fast P/Q calcium channel inactivation

21 January 2018

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The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner.

21 January 2018

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Alteration of Ca2+ dependence of neurotransmitter release by disruption of Ca2+ channel/syntaxin interaction.

21 January 2018

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Calcium channels: when is a subunit not a subunit?

30 October 2018

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12 December 2020

Expression of recombinant calcium channels support secretion in a mouse pheochromocytoma cell line

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12 December 2020

Inhibition of neurotransmission by peptides containing the synaptic protein interaction site of N-type Ca2+ channels

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12 December 2020

Rapid exocytosis in single chromaffin cells recorded from mouse adrenal slices

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12 December 2020

Reciprocal regulation of P/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin

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12 December 2020

Bidirectional modulation of transmitter release by calcium channel/syntaxin interactions in vivo

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0908359107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20080591%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

0 references

1 reference

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16 January 2020

PubMed publication ID

20080591

1 reference