The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers (Q33676423)

28 July 2017

The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers (English)

1 reference

28 July 2017

Jason M Fye

1

1 reference

28 July 2017

Stephanie R Coffin

2

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28 July 2017

Clinton D Orebaugh

3

1 reference

28 July 2017

Thomas Hollis

4

1 reference

28 July 2017

Fred W Perrino

5

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28 July 2017

language of work or name

English

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publication date

9 March 2014

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Journal of Biological Chemistry

28 July 2017

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28 July 2017

289

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28 July 2017

16

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28 July 2017

11556-11565

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describes a project that uses

28 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4036290/fullTextXML

inferred from PubMed Central ID database lookup

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Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease

21 June 2018

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The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity

21 June 2018

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21 June 2018

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Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease

21 June 2018

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C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

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A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus

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Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome

21 June 2018

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The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering

21 June 2018

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WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups

21 June 2018

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21 June 2018

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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

21 June 2018

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21 June 2018

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The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis

21 June 2018

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Cree encephalitis is allelic with Aicardi-Goutiéres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolism

21 June 2018

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Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins

21 June 2018

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Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes

21 June 2018

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A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein

21 June 2018

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Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases

21 June 2018

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Identification of a 3'-->5'-exonuclease that removes cytosine arabinoside monophosphate from 3' termini of DNA

21 June 2018

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Properties of Deoxyribonuclease III from Mammalian Tissues

21 June 2018

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Encephalitis among Cree children in northern Quebec

21 June 2018

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Intracranial metastasis of Wilms' tumor involving the tectal plate without pulmonary involvement. Case report.

21 June 2018

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Blue (or purple) toes: chilblains or chilblain lupus-like lesions are a manifestation of Aicardi-Goutières syndrome and familial chilblain lupus.

21 January 2018

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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

21 January 2018

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Rat Polymerase β Binds Double-Stranded DNA Using Exclusively the 8-kDa Domain. Stoichiometries, Intrinsic Affinities, and Cooperativities,

21 January 2018

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Exonucleases and the incorporation of aranucleotides into DNA.

21 January 2018

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Inherited or de novo mutation affecting aspartate 18 of TREX1 results in either familial chilblain lupus or Aicardi-Goutières syndrome.

30 October 2018

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12 December 2020

TREX1 gene variant in neuropsychiatric systemic lupus erythematosus

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12 December 2020

A general method of analysis of ligand binding to competing macromolecules using the spectroscopic signal originating from a reference macromolecule. Application to Escherichia coli replicative helicase DnaB protein nucleic acid interactions

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12 December 2020

Novel ophthalmic pathology in an autopsy case of autosomal dominant retinal vasculopathy with cerebral leukodystrophy

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12 December 2020

Identifiers

DOI

10.1074/JBC.M114.559252

1 reference

28 July 2017

1 reference

28 July 2017

1 reference