Pharmacodynamics and toxicodynamics of drug action: signaling in cell survival and cell death (Q33682659)

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28 July 2017

Yu R

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28 July 2017

Lei W

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28 July 2017

Fasanmande A

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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28 July 2017

1 June 1999

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28 July 2017

Pharmaceutical Research

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28 July 2017

16

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28 July 2017

790-798

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28 July 2017

6

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28 July 2017

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12 December 2020

An osmosensing signal transduction pathway in yeast.

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12 December 2020

Signal transduction through lipid second messengers

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12 December 2020

Regulation of Ras-mediated signalling: more than one way to skin a cat.

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12 December 2020

Signaling pathways in the induction of c-fos and c-jun proto-oncogenes by 3-methylcholanthrene.

1 reference

12 December 2020

Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz

1 reference

12 December 2020

Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs

1 reference

12 December 2020

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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12 December 2020

Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.

1 reference

12 December 2020

Regulation of CYP4A1 and peroxisome proliferator-activated receptor alpha expression by interleukin-1beta, interleukin-6, and dexamethasone in cultured fetal rat hepatocytes

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12 December 2020

The regulation of AP-1 activity by mitogen-activated protein kinases

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12 December 2020

Transcriptional regulation of multidrug resistance gene expression.

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12 December 2020

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun

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12 December 2020

Protein kinase cascades activated by stress and inflammatory cytokines

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12 December 2020

Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells.

1 reference

12 December 2020

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

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12 December 2020

Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

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12 December 2020

The significance of induced forestomach tumors

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12 December 2020

Brain lesions in an infant rhesus monkey treated with monsodium glutamate

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12 December 2020

Chemical and molecular regulation of enzymes that detoxify carcinogens

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12 December 2020

Hepatotoxicity of butylated hydroxytoluene and its analogs in mice depleted of hepatic glutathione

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12 December 2020

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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12 December 2020

P450 genes: structure, evolution, and regulation

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12 December 2020

Death and dying in the immune system

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12 December 2020

D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis

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12 December 2020

Caspases: enemies within

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12 December 2020

Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats

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12 December 2020

Differential requirement for caspase 9 in apoptotic pathways in vivo.

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12 December 2020

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

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12 December 2020

Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.

1 reference

12 December 2020

Differential activation of MAPK and ICE/Ced-3 protease in chemical-induced apoptosis. The role of oxidative stress in the regulation of mitogen-activated protein kinases (MAPKs) leading to gene expression and survival or activation of caspases leadi

1 reference

12 December 2020

Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1

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12 December 2020

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver

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12 December 2020

Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis

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12 December 2020

Induction of c-fos and c-jun gene expression by phenolic antioxidants.

1 reference

12 December 2020

Mitochondria and apoptosis

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12 December 2020

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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12 December 2020

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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12 December 2020

Activation of Raf as a result of recruitment to the plasma membrane

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12 December 2020

Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis

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12 December 2020

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

1 reference

12 December 2020

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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12 December 2020

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

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12 December 2020

Jun and Fos regulation of NAD(P)H: quinone oxidoreductase gene expression.

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12 December 2020

Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells

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12 December 2020

Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide

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12 December 2020

Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death

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12 December 2020

How MAP kinases are regulated

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12 December 2020

Transcription regulation of rat glutathione S-transferase Ya subunit gene expression by chemopreventive agents

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12 December 2020

Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.

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12 December 2020

Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis

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12 December 2020

Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2

1 reference

12 December 2020

Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells

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12 December 2020

Nomenclature for N-acetyltransferases

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12 December 2020

Differential expression of the phenol family of UDP-glucuronosyltransferases in hepatoma cell lines

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12 December 2020

Human ICE/CED-3 protease nomenclature

1 reference

12 December 2020

Ah receptor signaling pathways

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12 December 2020

Mitogen-activated protein kinase cascades as regulators of stress responses

1 reference

12 December 2020

Involvement of the N-methyl D-aspartate (NMDA) receptor in synapse elimination during cerebellar development

1 reference

12 December 2020

Activation of signal transduction kinases by tamoxifen

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12 December 2020

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

1 reference

12 December 2020

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element

1 reference

12 December 2020

Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis).

1 reference

12 December 2020

Parallel signal processing among mammalian MAPKs

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12 December 2020

Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases

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12 December 2020

Inhibition of caspase proteases by CrmA enhances the resistance of human leukemic cells to multiple chemotherapeutic agents

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12 December 2020

Functional antioxidant responsive elements.

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12 December 2020

Identification of a monocyte specific pre-interleukin 1 beta convertase activity

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12 December 2020

Regulation of gene expression of various phase I and phase II drug-metabolizing enzymes by tamoxifen in rat liver

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12 December 2020

Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death

1 reference

12 December 2020

Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase

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12 December 2020

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

12 December 2020

Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants

1 reference

12 December 2020

Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues

1 reference

12 December 2020

Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes

1 reference

12 December 2020

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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12 December 2020

Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity

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12 December 2020

The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression.

1 reference

12 December 2020

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis

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12 December 2020

The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation

1 reference

12 December 2020

Enhancement of glutathione S-transferase activity of the esophagus by phenols, lactones, and benzyl isothiocyanate

1 reference

12 December 2020

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element

1 reference

12 December 2020

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

1 reference

12 December 2020

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants

1 reference

12 December 2020

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

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12 December 2020

The riddle of MAP kinase signaling specificity

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12 December 2020

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

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12 December 2020

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence

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12 December 2020

T-cell regulation. Tails of phosphorylation and T-cell activation.

1 reference

12 December 2020

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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12 December 2020

c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis

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12 December 2020

The stress-activated protein kinase subfamily of c-Jun kinases

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12 December 2020

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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12 December 2020

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death

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12 December 2020

Bromocriptine transcriptionally activates the multidrug resistance gene (pgp2/mdr1b) by a novel pathway

1 reference

12 December 2020

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

1 reference

12 December 2020

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

1 reference

12 December 2020

Transcriptional regulation of the human quinone reductase gene by antiestrogen-liganded estrogen receptor-alpha and estrogen receptor-beta

1 reference

12 December 2020

Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis

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12 December 2020

The need for central and peripheral tolerance in the B cell repertoire

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12 December 2020

Regulation of cytochrome P450 gene transcription by phenobarbital

1 reference

12 December 2020

Peroxisome proliferator-activated receptors, orphans with ligands and functions

1 reference

12 December 2020

Apoptosis: a new pharmacodynamic endpoint

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12 December 2020

Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression.

1 reference

12 December 2020

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1 reference

12 December 2020

Role of oxidants and antioxidants in the induction of AP-1, NF-kappaB, and glutathione S-transferase gene expression

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12 December 2020

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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12 December 2020

Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention

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12 December 2020

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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12 December 2020

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme

1 reference

12 December 2020

Death receptors: signaling and modulation

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12 December 2020

Involvement of NF-kappa B in the induction of NAD(P)H:quinone oxidoreductase (DT-diaphorase) by hypoxia, oltipraz and mitomycin C.

1 reference

12 December 2020