Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents (Q33683449)

28 July 2017

title

Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents (English)

1 reference

28 July 2017

author name string

Katherine J Kayser-Bricker

1

1 reference

28 July 2017

Matthew P Glenn

2

1 reference

28 July 2017

Sang Hoon Lee

3

1 reference

28 July 2017

Said M Sebti

4

1 reference

28 July 2017

Jin Q Cheng

5

1 reference

28 July 2017

Andrew D Hamilton

6

1 reference

28 July 2017

language of work or name

English

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publication date

27 September 2008

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Bioorganic & Medicinal Chemistry

28 July 2017

published in

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28 July 2017

volume

17

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28 July 2017

issue

4

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28 July 2017

page(s)

1764-1771

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A novel substrate mimetic inhibitor of PKB/Akt inhibits prostate cancer tumor growth in mice by blocking the PKB pathway

28 July 2017

cites work

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Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics

21 June 2018

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

21 June 2018

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Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition

21 June 2018

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Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

21 June 2018

1 reference

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Designing bisubstrate analog inhibitors for protein kinases

21 June 2018

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Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design

21 June 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 June 2018

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Ten years of protein kinase B signalling: a hard Akt to follow

21 June 2018

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21 June 2018

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AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

21 June 2018

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Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

21 June 2018

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Cellular survival: a play in three Akts

21 June 2018

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 June 2018

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Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

21 June 2018

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A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

21 June 2018

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Three-dimensional structure of the Stat3beta homodimer bound to DNA

21 June 2018

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Mechanisms and consequences of activation of protein kinase B/Akt

21 June 2018

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Development and validation of a genetic algorithm for flexible docking

21 June 2018

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 June 2018

1 reference

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The AKT1 proto-oncogene maps to human chromosome 14, band q32.

21 June 2018

1 reference

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Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 June 2018

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Thymic lymphoma induction by the AKT8 murine retrovirus

21 June 2018

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Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

21 June 2018

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

21 June 2018

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Molecular cloning of a second form of rac protein kinase

21 June 2018

1 reference

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Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

21 June 2018

1 reference

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 June 2018

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Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

21 June 2018

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Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.

21 June 2018

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Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation

30 October 2018

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Structure-based optimization of novel azepane derivatives as PKB inhibitors

30 October 2018

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Development of an efficient procedure for indole ring synthesis from 2-ethynylaniline derivatives catalyzed by CuII salts and its application to natural product synthesis

30 October 2018

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A modified synthesis of iodoazidoaryl prazosin

30 October 2018

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30 October 2018

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19179081

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMC.2008.09.058

1 reference

28 July 2017

1 reference

28 July 2017

1 reference