Conformational effects of Lys191 in the human GnRH receptor: mutagenesis and molecular dynamics simulations studies. (Q33693003)

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22 January 2020

title

Conformational effects of Lys191 in the human GnRH receptor: mutagenesis and molecular dynamics simulations studies (English)

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22 January 2020

5

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22 January 2020

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P Michael Conn

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22 January 2020

author name string

Eduardo Jardón-Valadez

1

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22 January 2020

Arturo Aguilar-Rojas

2

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22 January 2020

Guadalupe Maya-Núñez

3

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22 January 2020

Alfredo Leaños-Miranda

4

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22 January 2020

Alfredo Ulloa-Aguirre

7

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22 January 2020

language of work or name

English

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publication date

26 February 2009

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22 January 2020

published in

Journal of Endocrinology

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22 January 2020

volume

201

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22 January 2020

issue

2

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22 January 2020

page(s)

297-307

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G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo

22 January 2020

cites work

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G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease

21 June 2018

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GROMACS: fast, flexible, and free

21 June 2018

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Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease

21 June 2018

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A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

21 June 2018

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Gonadotropin-releasing hormone receptors

21 June 2018

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GnRH II and type II GnRH receptors

21 June 2018

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Disulfide bonds and protein folding

21 June 2018

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The tail of the gonadotrophin-releasing hormone receptor: desensitization at, and distal to, G protein-coupled receptors.

21 June 2018

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Gonadotropin-releasing hormone receptors with intracellular carboxyl-terminal tails undergo acute desensitization of total inositol phosphate production and exhibit accelerated internalization kinetics

21 June 2018

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Static and dynamic roles of extracellular loops in G-protein-coupled receptors: a mechanism for sequential binding of thyrotropin-releasing hormone to its receptor.

21 June 2018

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VMD: visual molecular dynamics

21 June 2018

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Asn102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamide

21 June 2018

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Cloning and characterization of the human GnRH receptor

21 June 2018

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RASMOL: biomolecular graphics for all

21 June 2018

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Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms

21 June 2018

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On the control of gonadotropin secretion in the rhesus monkey

21 June 2018

1 reference

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Use of lithium ion in measurement of stimulated pituitary inositol phospholipid turnover

21 June 2018

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Specializations of a G-protein-coupled receptor that appear to aid with detection of frequency-modulated signals from its ligand.

21 June 2018

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Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy

30 October 2018

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Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants

30 October 2018

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Evolved regulation of gonadotropin-releasing hormone receptor cell surface expression

30 October 2018

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Receptor-misrouting: an unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism

30 October 2018

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Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target

30 October 2018

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Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site

30 October 2018

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Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: localization of attachment site to Cys residue in N-terminal segment

30 October 2018

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Effects of Asn318 and Asp87Asn318 mutations on signal transduction by the gonadotropin-releasing hormone receptor and receptor regulation

30 October 2018

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12 December 2020

In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles

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12 December 2020

Structure-activity relations of successful pharmacologic chaperones for rescue of naturally occurring and manufactured mutants of the gonadotropin-releasing hormone receptor

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12 December 2020

Influence of a species-specific extracellular amino acid on expression and function of the human gonadotropin-releasing hormone receptor

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12 December 2020

Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism

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12 December 2020

An intramolecular disulfide bond between conserved extracellular cysteines in the gonadotropin-releasing hormone receptor is essential for binding and activation

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12 December 2020

Modeling and molecular dynamics simulation of the human gonadotropin-releasing hormone receptor in a lipid bilayer

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12 December 2020

Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation

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12 December 2020

Identifiers

DOI

10.1677/JOE-08-0527

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22 January 2020

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22 January 2020

PubMed publication ID

19246515

1 reference