DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia (Q33694616)

28 July 2017

DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia (English)

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28 July 2017

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3

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2 June 2020

Chet E Holterman

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2 June 2020

author name string

Gabriel Lachance

1

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2 June 2020

James Uniacke

2

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2 June 2020

Aleksandra Franovic

5

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2 June 2020

Josianne Payette

6

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2 June 2020

Stephen Lee

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2 June 2020

language of work or name

English

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publication date

9 May 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

28 July 2017

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2 June 2020

volume

111

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2 June 2020

issue

21

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2 June 2020

page(s)

7783-7788

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The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

2 June 2020

cites work

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Influence of metabolism on epigenetics and disease

21 June 2018

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Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

21 June 2018

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Epigenetic abnormalities in cancer find a "home on the range"

21 June 2018

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Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.

21 June 2018

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SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.

21 June 2018

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Cancer epigenetics: from mechanism to therapy

21 June 2018

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Metabolic regulation of epigenetics

21 June 2018

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An oxygen-regulated switch in the protein synthesis machinery

21 June 2018

1 reference

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Functions of DNA methylation: islands, start sites, gene bodies and beyond

21 June 2018

1 reference

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Hypoxia-inducible factors in physiology and medicine

21 June 2018

1 reference

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Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene

21 June 2018

1 reference

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Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression

21 June 2018

1 reference

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Oxygen sensing, homeostasis, and disease

21 June 2018

1 reference

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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

21 June 2018

1 reference

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DNMT3A Mutations in Acute Myeloid Leukemia

21 June 2018

1 reference

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Hypoxia-inducible factors and the response to hypoxic stress

21 June 2018

1 reference

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Identification of preferential target sites for human DNA methyltransferases

21 June 2018

1 reference

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HIF-2alpha deletion promotes Kras-driven lung tumor development.

21 June 2018

1 reference

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Human cancers converge at the HIF-2alpha oncogenic axis.

21 June 2018

1 reference

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HIF-1: upstream and downstream of cancer metabolism

21 June 2018

1 reference

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HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice

21 June 2018

1 reference

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Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

21 June 2018

1 reference

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Regulation of endocytosis via the oxygen-sensing pathway

21 June 2018

1 reference

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Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes

21 June 2018

1 reference

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Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing

21 June 2018

1 reference

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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

21 June 2018

1 reference

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The epigenetic progenitor origin of human cancer

21 June 2018

1 reference

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A conserved family of prolyl-4-hydroxylases that modify HIF

21 June 2018

1 reference

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 June 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 June 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 June 2018

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 June 2018

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 June 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 June 2018

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Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha

21 June 2018

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Role for DNA methylation in genomic imprinting

21 June 2018

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Comparative pO2 measurements in cell spheroids cultured with different techniques

21 June 2018

1 reference

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4040594

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1322909111

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1322909111

Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1322909111

Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24817692

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1322909111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24817692%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24817692%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

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