The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. (Q33696467)

28 July 2017

title

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. (English)

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28 July 2017

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Tina Thorslund

1

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Michael J McIlwraith

Michael J McIlwraith

2

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Mark Petronczki

Mark Petronczki

5

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Stephen C. West

Stephen C West

7

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Sergey V. Lekomtsev

4

Sergey Lekomtsev

1 reference

28 July 2017

Sarah A Compton

3

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28 July 2017

Jack D Griffith

6

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28 July 2017

publication date

22 August 2010

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Nature Structural & Molecular Biology

28 July 2017

published in

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28 July 2017

volume

17

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28 July 2017

issue

10

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28 July 2017

page(s)

1263-1265

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

28 July 2017

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

Rad52 protein associates with replication protein A (RPA)-single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic complex formation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

Functional interactions among yeast Rad51 recombinase, Rad52 mediator, and replication protein A in DNA strand exchange

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

Internal repeats in the BRCA2 protein sequence

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041013

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

14 July 2018

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A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange

21 January 2018

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Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe

21 January 2018

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Cancer-associated mutations in BRC domains of BRCA2 affect homologous recombination induced by Rad51

21 January 2018

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Evidence that the tumor-suppressor protein BRCA2 does not regulate cytokinesis in human cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB.1905

1 reference

release_o2lc2nca6naqxoozdxxwnjoasm

28 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/o2lc2nca6naqxoozdxxwnjoasm

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4041013

1 reference

28 July 2017

1 reference