Target profiling of a small library of phosphodiesterase 5 (PDE5) inhibitors using chemical proteomics. (Q33700805)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Target profiling of a small library of phosphodiesterase 5 (PDE5) inhibitors using chemical proteomics (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Joost W Gouw

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Albert J.R. Heck

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

author name string

Poupak Dadvar

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Sarah Pelletier

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Klaus Rumpel

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

publication date

1 November 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

page(s)

1927-1936

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

14 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Overview of PDEs and their regulation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

https://api.crossref.org/works/10.1002%2FCMDC.201000303

1 reference

7 January 2021

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Tyrosine-612 in PDE5 contributes to higher affinity for vardenafil over sildenafil

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Cyclic nucleotide phosphodiesterases: relating structure and function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Cyclic nucleotide phosphodiesterase 5 and sildenafil: promises realized

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Potency, selectivity, and consequences of nonselectivity of PDE inhibition

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Phosphatidylethanolamine-binding proteins, including RKIP, exhibit affinity for phosphodiesterase-5 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Revealing promiscuous drug-target interactions by chemical proteomics.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Evaluation of kinase inhibitor selectivity by chemical proteomics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Target profiling of small molecules by chemical proteomics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Quantitative mass spectrometry in proteomics: a critical review

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Kinase selectivity profiling by inhibitor affinity chromatography

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Activity-based enrichment of matrix metalloproteinases using reversible inhibitors as affinity ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Quantitative chemical proteomics for identifying candidate drug targets

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Accurate quantitation of protein expression and site-specific phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Mass spectrometry-based quantitative proteomics.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Quantification in proteomics through stable isotope coding: a review

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Quantitative proteomics analysis of the secretory pathway

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

A model for random sampling and estimation of relative protein abundance in shotgun proteomics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Large-scale analysis of the yeast proteome by multidimensional protein identification technology

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Identification and relative quantitation of protein mixtures by enzymatic digestion followed by capillary reversed-phase liquid chromatography-tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Quantitative profiling of proteins in complex mixtures using liquid chromatography and mass spectrometry.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Quantification of proteins and metabolites by mass spectrometry without isotopic labeling or spiked standards

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Label-free mass spectrometry-based protein quantification technologies in proteomic analysis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Design of second generation phosphodiesterase 5 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Triplex protein quantification based on stable isotope labeling by peptide dimethylation applied to cell and tissue lysates

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Solubilization of membrane-bound rod phosphodiesterase by the rod phosphodiesterase recombinant delta subunit

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

cGMP is tightly bound to bovine retinal rod phosphodiesterase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Assigning significance to peptides identified by tandem mass spectrometry using decoy databases

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Qscore: an algorithm for evaluating SEQUEST database search results

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000303

7 January 2021

Identifiers

DOI

10.1002/CMDC.201000303

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20862763%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference