Chemical genetics: exploring and controlling cellular processes with chemical probes (Q33702202)

28 July 2017

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title

Chemical genetics: exploring and controlling cellular processes with chemical probes (English)

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28 July 2017

C M Crews

1

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PubMed ID

10431176

28 July 2017

U Splittgerber

series ordinal

2

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28 July 2017

1 August 1999

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28 July 2017

4

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Trends in Biochemical Sciences

inferred from page(s)

published in

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28 July 2017

24

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28 July 2017

8

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28 July 2017

317-320

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Towards a pharmacological genetics

28 July 2017

1 reference

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Chemical genetics resulting from a passion for synthetic organic chemistry.

1 reference

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The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

1 reference

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Structure of human methionine aminopeptidase-2 complexed with fumagillin

1 reference

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Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

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CRM1 is an export receptor for leucine-rich nuclear export signals

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CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1 reference

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Evidence for a role of CRM1 in signal-mediated nuclear protein export

1 reference

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Exportin 1 (Crm1p) is an essential nuclear export factor

1 reference

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The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin

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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

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Retinoblastoma protein recruits histone deacetylase to repress transcription

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Retinoblastoma protein represses transcription by recruiting a histone deacetylase

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Rb interacts with histone deacetylase to repress transcription

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Retinoblastoma protein meets chromatin

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The capsaicin receptor: a heat-activated ion channel in the pain pathway

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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

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Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

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Combinatorial chemistry

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The "One-Bead-One-Compound" Combinatorial Library Method

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Combinatorial diffusion assay used to identify topically active melanocyte-stimulating hormone receptor antagonists

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Parallel synthesis and screening of a solid phase carbohydrate library

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High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

1 reference

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Identifiers

DOI

1 reference

28 July 2017

1 reference

PubMed ID

10431176