Mechanism-based inhibition of ribonucleotide reductases: new mechanistic considerations and promising biological applications (Q33702981)

28 July 2017

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title

Mechanism-based inhibition of ribonucleotide reductases: new mechanistic considerations and promising biological applications (English)

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28 July 2017

Robins MJ

1

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28 July 2017

publication date

1 April 1999

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Nucleosides & nucleotides

28 July 2017

published in

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28 July 2017

volume

18

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28 July 2017

issue

4-5

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28 July 2017

page(s)

779-793

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Reduction of Ribonucleotides

28 July 2017

cites work

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From RNA to DNA, why so many ribonucleotide reductases?

21 January 2018

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Selective depletion of DNA precursors: an evolving strategy for potentiation of dideoxynucleoside activity against human immunodeficiency virus

21 January 2018

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Role of the M2 subunit of ribonucleotide reductase in regulation by hydroxyurea of the activity of the anti-HIV-1 agent 2',3'-dideoxyinosine

21 January 2018

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The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY).

21 January 2018

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Pharmacokinetics and pharmacodynamics of hydroxyurea

21 January 2018

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Metabolism and ribonucleotide reductase inhibition of (E)-2'-deoxy-2'-(fluoromethylene)cytidine, MDL 101,731, in human cervical carcinoma HeLa S3 cells.

21 January 2018

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Three-dimensional structure of the free radical protein of ribonucleotide reductase

21 January 2018

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Structure of ribonucleotide reductase protein R1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257779908041565

The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2

21 January 2018

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Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site

21 January 2018

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Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding

21 January 2018

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Interaction of C225SR1 mutant subunit of ribonucleotide reductase with R2 and nucleoside diphosphates: tales of a suicidal enzyme

21 January 2018

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A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase

21 January 2018

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Mechanism of inactivation of Escherichia coli ribonucleotide reductase by 2'-chloro-2'-deoxyuridine 5'-diphosphate: evidence for generation of a 2'-deoxy-3'-ketonucleotide via a net 1,2 hydrogen shift

21 January 2018

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Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine 5'-diphosphate.

21 January 2018

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Inhibition of ribonucleotide reductase by 2'-substituted deoxycytidine analogs: possible application in AIDS treatment

21 January 2018

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Biological activity and phosphorylation of 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine

21 January 2018

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Inactivation of Escherichia coli ribonucleotide reductase by 2'-deoxy-2'-mercaptouridine 5'-diphosphate. Electron paramagnetic resonance evidence for a transient protein perthiyl radical.

21 January 2018

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A New Photochemical Reaction1

21 January 2018

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10.1080/15257779908041565

21 January 2018

Identifiers

DOI

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28 July 2017

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