Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites (Q33709247)

28 July 2017

1 reference

title

Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites (English)

1 reference

28 July 2017

Moroni F

1

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PubMed ID

10443567

28 July 2017

language of work or name

English

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publication date

1 June 1999

1 reference

European Journal of Pharmacology

28 July 2017

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28 July 2017

375

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28 July 2017

87-100

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28 July 2017

1-3

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Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate beta-lyase

28 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Isolation and expression of a cDNA clone encoding human kynureninase

7 January 2021

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Regulation of the kynurenine pathway by IFN-gamma in murine cloned macrophages and microglial cells

7 January 2021

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Cloning and functional expression of human kynurenine 3-monooxygenase

7 January 2021

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Presence of 3-hydroxyanthranilic acid in rat tissues and evidence for its production from anthranilic acid in the brain.

7 January 2021

1 reference

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Quinolinic acid in vivo synthesis rates, extracellular concentrations, and intercompartmental distributions in normal and immune-activated brain as determined by multiple-isotope microdialysis.

7 January 2021

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Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

7 January 2021

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Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions

7 January 2021

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The preferred route of kynurenine metabolism in the rat

7 January 2021

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Brain tryptophan hydroxylation in the portacaval shunted rat: a hypothesis for the regulation of serotonin turnover in vivo

7 January 2021

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Quinolinic acid accumulation and functional deficits following experimental spinal cord injury

7 January 2021

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7 January 2021

Much IDO about pregnancy

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Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney

7 January 2021

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THE role of indoleamine 2,3-dioxygenase in the anti-tumour activity of human interferon-γin vivo

7 January 2021

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1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

7 January 2021

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Interferons and indoleamine 2,3-dioxygenase: role in antimicrobial and antitumor effects

7 January 2021

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Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.

7 January 2021

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Identification and measurement of oxindole (2-indolinone) in the mammalian brain and other rat organs

7 January 2021

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Molecular characterisation of kynurenine pathway enzymes. 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase

7 January 2021

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Effects of mitochondria and o-methoxybenzoylalanine on 3-hydroxyanthranilic acid dioxygenase activity and quinolinic acid synthesis.

7 January 2021

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Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase.

7 January 2021

1 reference

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Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase

7 January 2021

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Glutamate neurotoxicity and diseases of the nervous system

7 January 2021

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Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity

7 January 2021

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High activities of glutamine transaminase K (dichlorovinylcysteine beta-lyase) and omega-amidase in the choroid plexus of rat brain

7 January 2021

1 reference

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Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.

7 January 2021

1 reference

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Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA

7 January 2021

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Effects of central administration of kynurenic acid on spontaneous locomotor activity in the kindled rat: a multivariate approach using the automated Digiscan monitoring system

7 January 2021

1 reference

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Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells

7 January 2021

1 reference

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Localization of kynurenine aminotransferase immunoreactivity in the rat hippocampus

7 January 2021

1 reference

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Kynurenine pathway enzymes in a rat model of chronic epilepsy: immunohistochemical study of activated glial cells.

7 January 2021

1 reference

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Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line

7 January 2021

1 reference

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A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine

7 January 2021

1 reference

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Interferon gamma-resistant mutants are defective in the induction of indoleamine 2,3-dioxygenase

7 January 2021

1 reference

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Selective sparing of a class of striatal neurons in Huntington's disease

7 January 2021

1 reference

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Neurotoxin quinolinic acid is selectively elevated in spinal cords of rats with experimental allergic encephalomyelitis

7 January 2021

1 reference

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On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds

7 January 2021

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Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro

7 January 2021

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Blood?Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism

7 January 2021

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Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil.

7 January 2021

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Factors influencing effect of hydrocortisone on rat brain tryptophan metabolism

7 January 2021

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Increased concentrations of 3-hydroxykynurenine in vitamin B6 deficient neonatal rat brain.

7 January 2021

1 reference

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Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations

7 January 2021

1 reference

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Delayed increases in regional brain quinolinic acid follow transient ischemia in the gerbil.

7 January 2021

1 reference

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Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease

7 January 2021

1 reference

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Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

7 January 2021

1 reference

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Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types

7 January 2021

1 reference

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Metal-mediated oxidative damage to cellular and isolated DNA by certain tryptophan metabolites.

7 January 2021

1 reference

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Interference with cellular energy metabolism reduces kynurenic acid formation in rat brain slices: reversal by lactate and pyruvate.

7 January 2021

1 reference

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Immuno-localization of kynurenine aminotransferase (KAT) in the rat medulla and spinal cord.

7 January 2021

1 reference

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Preliminary X-ray crystallographic analysis of tryptophanase from Escherichia coli.

7 January 2021

1 reference

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Quinolinate neurotoxicity in cortical cell culture.

7 January 2021

1 reference

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The adaptive increase of the tryptophan peroxidase-oxidase system of liver

7 January 2021

1 reference

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Localization of quinolinic acid metabolizing enzymes in the rat brain. Immunohistochemical studies using antibodies to 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase

7 January 2021

1 reference

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Importance of the two interferon-stimulated response element (ISRE) sequences in the regulation of the human indoleamine 2,3-dioxygenase gene

7 January 2021

1 reference

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Depressor effect of kynurenine and its metabolites in rats

7 January 2021

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7 January 2021

Kynurenines and Seizures

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Convulsant action of intracerebroventricularly administered l-kynurenine sulphate, quinolinic acid and other derivatives of succinic acid, and effects of amino acids: structure-activity relationships

7 January 2021

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Interferon-gamma-induced activation of indoleamine 2,3-dioxygenase in cord blood monocyte-derived macrophages inhibits the growth of group B streptococci

7 January 2021

1 reference

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Deduced primary structure of rat tryptophan-2,3-dioxygenase

7 January 2021

1 reference

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Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain

7 January 2021

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Isolation and characterization of an hydroxykynureninase from homogenates of adult mouse liver

7 January 2021

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A comparison of the effects of N-methyl-d-aspartate and quinolinate on central neurones of the rat

7 January 2021

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Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters

7 January 2021

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Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid.

7 January 2021

1 reference

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Quinolinate differentiates between forebrain and cerebellar NMDA receptors

7 January 2021

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The excitotoxin quinolinic acid is present and unevenly distributed in the rat brain

7 January 2021

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The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

7 January 2021

1 reference

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Presence of Kynurenic Acid in the Mammalian Brain

7 January 2021

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Modulation of Quinolinic and Kynurenic Acid Content in the Rat Brain: Effects of Endotoxins and Nicotinylalanine

7 January 2021

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NMDA receptor heterogeneity in mammalian tissues: focus on two agonists, (2S,3R,4S) cyclopropylglutamate and the sulfate ester of 4-hydroxy-(S)-pipecolic acid.

7 January 2021

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Kynurenine hydroxylase and kynureninase inhibitors as tools to study the role of kynurenine metabolites in the central nervous system

7 January 2021

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Oxindole in pathogenesis of hepatic encephalopathy

7 January 2021

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Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex.

7 January 2021

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Neuroprotective effects of kynurenine-3-hydroxylase inhibitors in models of brain ischemia

7 January 2021

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Molecular cloning of rat kynurenine aminotransferase: identity with glutamine transaminase K.

7 January 2021

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Prevention of allogeneic fetal rejection by tryptophan catabolism

7 January 2021

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3-Hydroxykynurenine toxicity on the rat striatum in vivo

7 January 2021

1 reference

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Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.

7 January 2021

1 reference

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Kynureninase and Kynurenine 3-Hydroxylase in Mammalian Tissues

7 January 2021

1 reference

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Two kynurenine aminotransferases in human brain

7 January 2021

1 reference

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Excitotoxic amino acids and neuropsychiatric disorders

7 January 2021

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Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

7 January 2021

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Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: a potent inhibitor of 3-hydroxyanthranilic acid oxidase.

7 January 2021

1 reference

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Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage.

7 January 2021

1 reference

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The glycine antagonist and free radical scavenger 7-Cl-thio-kynurenate reduces CA1 ischemic damage in the gerbil

7 January 2021

1 reference

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Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.

7 January 2021

1 reference

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An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.

7 January 2021

1 reference

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Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan

7 January 2021

1 reference

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Experimental convulsions in rats induced by intraventricular administration of kynurenine and structurally related compounds

7 January 2021

1 reference

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Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice.

7 January 2021

1 reference

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3-Hydroxyanthranilic acid oxygenase-containing astrocytic processes surround glutamate-containing axon terminals in the rat striatum

7 January 2021

1 reference

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Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

The NMDA receptor, NMDA antagonists and epilepsy therapy. A status report

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.

7 January 2021

1 reference

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6-Chloro-D,L-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation.

7 January 2021

1 reference

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The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Inhibition of nitric oxide synthase expression and activity in macrophages by 3-hydroxyanthranilic acid, a tryptophan metabolite

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

High-affinity uptake of L-kynurenine by a Na+-independent transporter of neutral amino acids in astrocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

(R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Quinolinic acid and other kynurenines in the central nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Cloning and recombinant expression of rat and human kynureninase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

L-kynurenine 3-monooxygenase from mitochondrial outer membrane of pig liver: purification, some properties, and monoclonal antibodies directed to the enzyme

7 January 2021

1 reference

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Different stereoselectivity of the enantiomers of HA-966 (3-amino-1-hydroxy-2-pyrrolidinone) for neuroprotective and anticonvulsant actions in vivo

7 January 2021

1 reference

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Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Immunohistochemical localization of indoleamine 2,3-dioxygenase in the argyrophilic cells of rabbit duodenum and thyroid gland

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system

7 January 2021

1 reference

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Identification of quinolinic acid in rat and human brain tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Indoleamine 2,3-dioxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Interferon: a mediator of indoleamine 2,3-dioxygenase induction by lipopolysaccharide, poly(I) X poly(C), and pokeweed mitogen in mouse lung

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

Modulation of cellular tryptophan metabolism in human fibroblasts by transforming growth factor-beta: selective inhibition of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

[3H]homoquinolinate binds to a subpopulation of NMDA receptors and to a novel binding site.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

7 January 2021

Oxindole, a sedative tryptophan metabolite, accumulates in blood and brain of rats with acute hepatic failure.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

7 January 2021

Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

7 January 2021

Organ distribution of rat kynureninase and changes of its activity during development.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

7 January 2021

3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

7 January 2021

Quinolinic acid in neurological disease: opportunities for novel drug discovery.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

7 January 2021

Induction of indoleamine 2,3-dioxygenase in tumor cells transplanted into allogeneic mouse: interferon-gamma is the inducer.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900196-X

7 January 2021

10.1016/S0014-2999(99)00196-X

Identifiers

DOI

1 reference

28 July 2017

1 reference

PubMed ID

10443567