The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance (Q33719096)

28 July 2017

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title

The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance (English)

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28 July 2017

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Downing JR

1

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PubMed ID

10460585

28 July 2017

language of work or name

English

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publication date

1 August 1999

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British Journal of Haematology

28 July 2017

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28 July 2017

106

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28 July 2017

2

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28 July 2017

296-308

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The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates

28 July 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Groucho-dependent and -independent repression activities of Runt domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The capacity of polyomavirus enhancer binding protein 2alphaB (AML1/Cbfa2) to stimulate polyomavirus DNA replication is related to its affinity for the nuclear matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Differentiation dependent expression and distinct subcellular localization of the protooncogene product, PEBP2beta/CBFbeta, in muscle development

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

TCF/LEF factor earn their wings

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Leukaemia/Drosophila homology

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

ETS-core binding factor: a common composite motif in antigen receptor gene enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The AML1/ETO fusion protein activates transcription of BCL-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA binding ability and the transforming activity on fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Role of the histone deacetylase complex in acute promyelocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The transcriptional coactivators p300 and CBP are histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

What's up and down with histone deacetylation and transcription?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Expression of runt in the mouse embryo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Tumourigenicity of MTG8, a leukaemia-related gene, in concert with v-Ha-ras gene in BALB/3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The protooncogene product, PEBP2beta/CBFbeta, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Cooperative binding of Ets-1 and core binding factor to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

Targeting frequency for deletion vectors in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

The nucleosome core all wrapped up

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2141.1999.01377.X

10.1046/J.1365-2141.1999.01377.X

21 January 2018

Identifiers

DOI

1 reference

28 July 2017

1 reference

PubMed ID

10460585