Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine (Q33723645)

28 July 2017

Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine (English)

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28 July 2017

G Smith

1

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28 July 2017

R Bounds

2

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28 July 2017

H Wolf

3

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28 July 2017

R J C Steele

4

1 reference

28 July 2017

F A Carey

5

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28 July 2017

C R Wolf

6

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28 July 2017

language of work or name

English

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publication date

1 February 2010

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British Journal of Cancer

28 July 2017

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28 July 2017

102

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28 July 2017

4

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28 July 2017

693-703

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https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605534

28 July 2017

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cites work

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KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer.

21 June 2018

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Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

21 June 2018

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High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

21 June 2018

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Understanding the predictive role of K-ras for epidermal growth factor receptor-targeted therapies in colorectal cancer.

21 June 2018

1 reference

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Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

21 June 2018

1 reference

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Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes

21 June 2018

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Dual-specificity MAP kinase phosphatases (MKPs) and cancer

21 June 2018

1 reference

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Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation

21 June 2018

1 reference

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Recurrent KRAS codon 146 mutations in human colorectal cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Tumor predisposition in Costello syndrome

21 June 2018

1 reference

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The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines

21 June 2018

1 reference

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The RAF proteins take centre stage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Genetic predisposition to colorectal cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Gene profiling of a myeloma cell line reveals similarities and unique signatures among IL-6 response, N-ras-activating mutations, and coculture with bone marrow stromal cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Mutations of the BRAF gene in human cancer

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

The importance of being K-Ras

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Genetic alterations during colorectal-tumor development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

ras oncogenes in human cancer: a review

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Neutron radiation can activate K-ras via a point mutation in codon 146 and induces a different spectrum of ras mutations than does gamma radiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Hamster cell line suitable for transfection assay of transforming genes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

ras oncogenes: their role in neoplasia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837563

Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.

21 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605534

K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605534

Concurrent mutations of K-ras oncogene at codons 12 and 22 in colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605534

Setting future standards for KRAS testing in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605534

Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605534

Characterization of a novel oncogenic K-ras mutation in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605534

Detection of single-nucleotide polymorphisms with the WAVE DNA fragment analysis system

21 January 2018

1 reference

12 December 2020

A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction

1 reference

12 December 2020

H-ras mutations in human pituitary carcinoma metastases

1 reference

12 December 2020

Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas

1 reference

12 December 2020

Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab

1 reference

12 December 2020

Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone

1 reference

12 December 2020

KRAS mutation profile in colorectal carcinoma and novel mutation--internal tandem duplication in KRAS

1 reference

12 December 2020

K-Ras mutations are changing practice in advanced colorectal cancer

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6605534

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Dimensions Publication ID

28 July 2017

0 references

1 reference

28 July 2017

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