Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase. (Q33724342)

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English	Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase.	scientific article

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scholarly article

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9 November 2019

Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase (English)

1 reference

Europe PubMed Central

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9 November 2019

Streptomyces hygroscopicus

object named as

Streptomyces hygroscopicus

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L E Khaw

1

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9 November 2019

G A Böhm

2

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9 November 2019

S Metcalfe

3

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9 November 2019

J Staunton

4

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9 November 2019

P F Leadlay

5

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9 November 2019

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1 February 1998

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9 November 2019

Journal of Bacteriology

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9 November 2019

180

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9 November 2019

4

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9 November 2019

809-814

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9 November 2019

Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

Gene disruption and replacement in the rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

Ornithine cyclodeaminase from Ti plasmid C58: DNA sequence, enzyme properties and regulation of activity by arginine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

Ornithine cyclodeaminase from octopine Ti plasmid Ach5: identification, DNA sequence, enzyme properties, and comparison with gene and enzyme from nopaline Ti plasmid C58.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

Biosynthesis of the immunosuppressant immunomycin: the enzymology of pipecolate incorporation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

Cloning and location of a gene governing lysine epsilon-aminotransferase, an enzyme initiating beta-lactam biosynthesis in Streptomyces spp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

In vivo immunopharmacology of the macrolides FK 506 and rapamycin: toward the era of rational immunosuppressive drug discovery, development, and use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

21 June 2018

The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=106958

30 October 2018

General method for the determination of precursor configuration in biosynthetic precursor-product relations. Derivation of pipecolic acid from D-lysine, and of piperidine alkaloids from L-lysine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9473033

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Revised NMR assignments for rapamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9473033

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of novel rapamycin structures by microbial manipulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/9473033

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9473033

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ornithine cyclase (deaminating). III. Mechanism of the conversion of ornithine to proline

1 reference

https://pubmed.ncbi.nlm.nih.gov/9473033

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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9 November 2019

1 reference

Europe PubMed Central

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9 November 2019

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