Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth (Q33732486)

29 July 2017

Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth (English)

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29 July 2017

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Hiroya Hashizume

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29 July 2017

Beverly L Falcón

2

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29 July 2017

Takashi Kuroda

3

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29 July 2017

Peter Baluk

4

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29 July 2017

Angela Coxon

5

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29 July 2017

Dongyin Yu

6

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29 July 2017

James V Bready

7

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29 July 2017

Jonathan D Oliner

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29 July 2017

Donald M McDonald

9

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29 July 2017

language of work or name

English

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publication date

2 March 2010

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29 July 2017

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29 July 2017

70

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6

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29 July 2017

2213-2223

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describes a project that uses

29 July 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2840050/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels

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Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic mice

21 June 2018

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Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

21 June 2018

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

21 June 2018

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Angiopoietin-2: development of inhibitors for cancer therapy

21 June 2018

1 reference

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Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth

21 June 2018

1 reference

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Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1

21 June 2018

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Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

21 June 2018

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HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

21 June 2018

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Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels

21 June 2018

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Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer

21 June 2018

1 reference

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Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102

21 June 2018

1 reference

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Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors

21 June 2018

1 reference

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Angiopoietins: a link between angiogenesis and inflammation.

21 June 2018

1 reference

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AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts

21 June 2018

1 reference

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Lessons from phase III clinical trials on anti-VEGF therapy for cancer

21 June 2018

1 reference

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Angiogenesis as a therapeutic target

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma

21 June 2018

1 reference

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

21 June 2018

1 reference

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Hypoxia and defective apoptosis drive genomic instability and tumorigenesis

21 June 2018

1 reference

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Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts

21 June 2018

1 reference

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Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Regression of established tumors and metastases by potent vascular endothelial growth factor blockade

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

The role of VEGF in normal and neoplastic hematopoiesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Angiopoietin-2 is implicated in the regulation of tumor angiogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Vascular-specific growth factors and blood vessel formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Angiopoietin decoy secreted at tumor site impairs tumor growth and metastases by inducing local inflammation and altering neoangiogenesis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840050

Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20197469

12 December 2020

inferred from PubMed ID database lookup

The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20197469

12 December 2020

inferred from PubMed ID database lookup

Tumor biology: use of tiled images in conjunction with measurements of cellular proliferation and death in response to drug treatments

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20197469

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/0008-5472.CAN-09-1977

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29 July 2017

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29 July 2017

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