mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. (Q33734395)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20167806%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis (English)

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18 January 2020

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corrigendum / erratum

Correction for Laplante et al., mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis

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author

David M. Sabatini

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20167806%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Mathieu Laplante

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20167806%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

English

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publication date

18 February 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20167806%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

18 January 2020

published in

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18 January 2020

volume

107

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18 January 2020

issue

8

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18 January 2020

page(s)

3281-3282

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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

18 January 2020

cites work

1 reference

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An emerging role of mTOR in lipid biosynthesis.

21 June 2018

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mTOR signaling at a glance

21 June 2018

1 reference

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GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

21 June 2018

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

21 June 2018

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AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells

21 June 2018

1 reference

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

21 June 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 June 2018

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21 June 2018

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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

21 June 2018

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Selective versus total insulin resistance: a pathogenic paradox

21 June 2018

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AKT/PKB signaling: navigating downstream

21 June 2018

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SREBP-1c transcription factor and lipid homeostasis: clinical perspective

21 June 2018

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Inflammation and metabolic disorders

21 June 2018

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Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

21 June 2018

1 reference

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 June 2018

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Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

21 June 2018

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The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

21 June 2018

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Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

21 June 2018

1 reference

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Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis?

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1000323107

The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1000323107

Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1000323107

21 January 2018

Identifiers

DOI

10.1073/PNAS.1000323107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20167806%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20167806%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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