Adefovir dipivoxil (Q33736276)

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Language	Label	Description	Also known as
English	Adefovir dipivoxil	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

Adefovir dipivoxil (English)

1 reference

Europe PubMed Central

29 July 2017

author name string

S Noble

1

1 reference

Europe PubMed Central

29 July 2017

K L Goa

2

1 reference

Europe PubMed Central

29 July 2017

publication date

1 September 1999

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

58

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Europe PubMed Central

29 July 2017

3

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Europe PubMed Central

29 July 2017

479-87; discussion 488-9

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Europe PubMed Central

29 July 2017

https://scigraph.springernature.com/pub.10.2165/00003495-199958030-00010

0 references

Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected [...]

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from AIDS patients after prolonged adefovir dipivoxil therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human immunodeficiency virus type 1 expressing the lamivudine-associated M184V mutation in reverse transcriptase shows increased susceptibility to adefovir and decreased replication capability in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular uptake of phosphonylmethoxyalkylpurine derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10493275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003495-199958030-00010

1 reference

Europe PubMed Central

29 July 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

29 July 2017

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