Initiation of autoimmunity by a reactive metabolite of a lupus-inducing drug in the thymus (Q33741226)

29 July 2017

1 reference

24 June 2021

Initiation of autoimmunity by a reactive metabolite of a lupus-inducing drug in the thymus (English)

1 reference

systemic lupus erythematosus

29 July 2017

main subject

1 reference

pharmaceutical preparation

6 August 2019

1 reference

6 August 2019

adverse drug reaction

1 reference

23 November 2020

1 reference

24 June 2021

R L Rubin

1

1 reference

29 July 2017

A Kretz-Rommel

series ordinal

2

1 reference

29 July 2017

publication date

1 October 1999

8 references

Environmental Health Perspectives

29 July 2017

12 March 2019

13 March 2019

17 June 2019

30 June 2019

6 August 2019

23 November 2020

24 June 2021

8 references

29 July 2017

12 March 2019

13 March 2019

17 June 2019

30 June 2019

6 August 2019

23 November 2020

24 June 2021

107 Suppl 5

1 reference

29 July 2017

page(s)

803-806

1 reference

Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

T Lymphocytes Ignore Procainamide, but Respond to Its Reactive Metabolites in Peritoneal Cells: Demonstration by the Adoptive Transfer Popliteal Lymph Node Assay

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Reactivity and possible significance of hydroxylamine and nitroso metabolites of procainamide

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Cytotoxicity of oxidative metabolites of procainamide.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Changes in the human thymus during aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

The immunologic and metabolic basis of drug hypersensitivities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Metabolism of procainamide to a hydroxylamine by human neutrophils and mononuclear leukocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Metabolism of procainamide to the cytotoxic hydroxylamine by neutrophils activated in vitro

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Electrochemical determination of N-oxidized procainamide metabolites and functional assessment of effects on murine cells in vitro

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Metabolism of hydralazine by activated leukocytes: implications for hydralazine induced lupus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Metabolism of isoniazid by activated leukocytes. Possible role in drug-induced lupus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Comparative metabolism and covalent binding of procainamide by human leukocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Autoimmunization and lymphomagenesis in parent to F1 combinations differing at the major histocompatibility complex: model for spontaneous disease caused by altered self-antigens?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Persistence of autoreactive T cell drive is required to elicit anti-chromatin antibodies in a murine model of drug-induced lupus.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

The effect of thymic function on immunocompetence following bone marrow transplantation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Thymic microenvironmental abnormalities and thymic selection in NZB.H-2bm12 mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Clinical pharmacology. Adverse reactions to drugs.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Immunomodulatory effects of procainamide metabolites: their implications in drug-related lupus

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Phenotypic and Immunohistological Analyses of the Human Adult Thymus: Evidence for an Active Thymus during Adult Life

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566244

Changes in thymic function with age and during the treatment of HIV infection

30 October 2018

1 reference

12 December 2020

Transformation of lupus-inducing drugs to cytotoxic products by activated neutrophils

1 reference

12 December 2020

Rheumatic and febrile syndrome during prolonged hydralazine treatment

1 reference

12 December 2020

Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes

1 reference

12 December 2020

Studies on the control of hypertension by hyphex. II. Toxic reactions and side effects

1 reference

12 December 2020

Enzyme-mediated covalent binding of hydralazine to rat liver microsomes

1 reference

12 December 2020

Metabolic activation of chlorpromazine by stimulated human polymorphonuclear leukocytes. Induction of covalent binding of chlorpromazine to nucleic acids and proteins

1 reference

12 December 2020

The formation of procainamide hydroxylamine by rat and human liver microsomes

1 reference

12 December 2020

Increase in antioxidant activity in procainamide-treated rats

1 reference

12 December 2020

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1 reference

12 December 2020

Effects of procainamide hydroxylamine on generation of reactive oxygen species by macrophages and production of cytokines

1 reference

12 December 2020

V beta gene repertoires in aging mice

1 reference

12 December 2020

Procainamide hydroxylamine lymphocyte toxicity—I. Evidence for participation by hemoglobin

1 reference

12 December 2020

Free radical production and site-specific DNA damage induced by hydralazine in the presence of metal ions or peroxidase/ hydrogen peroxide

1 reference

12 December 2020

Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution

1 reference

12 December 2020

On the mechanism of peroxidase-catalyzed oxygen production

1 reference

12 December 2020

Oxidation of propylthiouracil to reactive metabolites by activated neutrophils. Implications for agranulocytosis

1 reference

12 December 2020

Identifiers

DOI

10.1289/EHP.99107S5803

1 reference

29 July 2017

1 reference

29 July 2017

1 reference