Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC (Q33745769)

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English	Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC	scientific article

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scholarly article

1 reference

Europe PubMed Central

29 July 2017

Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC (English)

1 reference

Europe PubMed Central

29 July 2017

0 references

diabetic nephropathy

1 reference

based on heuristic

inferred from title

Lynetta Phillips

2

object named as

Lynetta Phillips

1 reference

Europe PubMed Central

29 July 2017

author name string

Jun Ma

1

1 reference

Europe PubMed Central

29 July 2017

Ying Wang

3

1 reference

Europe PubMed Central

29 July 2017

Tiane Dai

4

1 reference

Europe PubMed Central

29 July 2017

Janine LaPage

5

1 reference

Europe PubMed Central

29 July 2017

Rama Natarajan

6

1 reference

Europe PubMed Central

29 July 2017

Sharon G Adler

7

1 reference

Europe PubMed Central

29 July 2017

publication date

12 November 2010

1 reference

Europe PubMed Central

29 July 2017

BMC Complementary and Alternative Medicine

1 reference

Europe PubMed Central

29 July 2017

10

1 reference

Europe PubMed Central

29 July 2017

67

1 reference

Europe PubMed Central

29 July 2017

https://scigraph.springernature.com/pub.10.1186/1472-6882-10-67

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The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

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21 June 2018

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21 June 2018

Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma

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21 June 2018

Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway

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21 June 2018

Cell cycle inhibition and apoptosis induced by curcumin in Ewing sarcoma cell line SK-NEP-1.

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21 June 2018

Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK.

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21 June 2018

Inhibition of p300 and nuclear factor-kappaB by curcumin and its role in diabetic nephropathy

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21 June 2018

Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes

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21 June 2018

Biphasic activation of p38MAPK suggests that apoptosis is a downstream event in pemphigus acantholysis

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Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

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Curcumin-induced fibroblast apoptosis and in vitro wound contraction are regulated by antioxidants and heme oxygenase: implications for scar formation.

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21 June 2018

Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy.

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21 June 2018

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

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21 June 2018

Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK

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21 June 2018

HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells

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21 June 2018

The actin cytoskeleton: a key regulator of apoptosis and ageing?

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21 June 2018

Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets

1 reference

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21 June 2018

Curcumin inhibits ROS formation and apoptosis in methylglyoxal-treated human hepatoma G2 cells

1 reference

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21 June 2018

Curcumin prevents methylglyoxal-induced oxidative stress and apoptosis in mouse embryonic stem cells and blastocysts

1 reference

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21 June 2018

Induction of apoptosis by curcumin and its implications for cancer therapy

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21 June 2018

Activation and signaling of the p38 MAP kinase pathway

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21 June 2018

Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons.

1 reference

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21 June 2018

Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells

1 reference

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21 June 2018

Proteinuria and its consequences in renal disease.

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21 June 2018

Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice11See Editorial by Kasinath, p. 1918

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21 June 2018

HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation

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21 June 2018

Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation

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21 June 2018

Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis

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Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells

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21 June 2018

Hsp27 regulates podocyte cytoskeletal changes in an in vitro model of podocyte process retraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999583

21 June 2018

Hsp27 as a negative regulator of cytochrome C release

1 reference

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21 June 2018

Curcumin, a medicinal herbal compound capable of inducing the heat shock response

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21 June 2018

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

1 reference

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21 June 2018

Cytoprotective effect of curcumin in human proximal tubule epithelial cells exposed to shiga toxin

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21 June 2018

Stress and molecular chaperones in disease

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21 June 2018

Hsp27 negatively regulates cell death by interacting with cytochrome c.

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21 June 2018

Stimulation of the stress-induced expression of stress proteins by curcumin in cultured cells and in rat tissues in vivo

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21 June 2018

A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini

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21 June 2018

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death

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21 June 2018

Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells

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21 June 2018

Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.

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21 June 2018

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27.

1 reference

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21 June 2018

Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells

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21 June 2018

Na+/Pi co-transport alters rapidly cytoskeletal protein polymerization dynamics in opossum kidney cells

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21 June 2018

Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells

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21 June 2018

Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance

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21 June 2018

Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27

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21 June 2018

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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21 June 2018

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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21 June 2018

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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21 June 2018

A 12-lipoxygenase product of arachidonate metabolism is involved in angiotensin action on renin release

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21 June 2018

Selective assay of monomeric and filamentous actin in cell extracts, using inhibition of deoxyribonuclease I.

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21 June 2018

G proteins and small GTPases: distant relatives keep in touch.

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21 January 2018

Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes.

1 reference

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21 January 2018

Phosphatase inhibitors prevent HSP27 dephosphorylation, destruction of stress fibrils, and morphological changes in endothelial cells during ATP depletion

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21 January 2018

Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis

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21 January 2018

Control of actin dynamics by p38 MAP kinase - Hsp27 distribution in the lamellipodium of smooth muscle cells.

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21 January 2018

Hsp27 associates with actin and limits injury in energy depleted renal epithelia

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21 January 2018

Glucose and diabetes: effects on podocyte and glomerular p38MAPK, heat shock protein 25, and actin cytoskeleton

1 reference

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21 January 2018

Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells

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21 January 2018

Curcumin in plasma and urine: quantitation by high-performance liquid chromatography

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21 January 2018

Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation

1 reference

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21 January 2018

Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells

1 reference

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21 January 2018

Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells

1 reference

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21 January 2018

Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells.

1 reference

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21 January 2018

Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.

1 reference

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21 January 2018

Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner

1 reference

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21 January 2018

Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB.

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21 January 2018

Influence of SB203580 on cell apoptosis and P38MAPK in renal ischemia/reperfusion injury.

1 reference

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21 January 2018

Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway

1 reference

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21 January 2018

Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light.

1 reference

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21 January 2018

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1 reference

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21 January 2018

Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells.

1 reference

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21 January 2018

Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.

1 reference

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21 January 2018

HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction

1 reference

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21 January 2018

Actin is cleaved during constitutive apoptosis

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21 January 2018

Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents

1 reference

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21 January 2018

12-lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy

1 reference

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21 January 2018

Interaction of MAPK and 12-lipoxygenase pathways in growth and matrix protein expression in mesangial cells

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21 January 2018

12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat.

1 reference

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21 January 2018

Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells

1 reference

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30 October 2018

Curcumin-induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells

1 reference

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30 October 2018

Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence.

1 reference

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30 October 2018

Rho controls actin cytoskeletal assembly in renal epithelial cells during ATP depletion and recovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999583

30 October 2018

A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease.

1 reference

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30 October 2018

Small heat shock protein alteration provides a mechanism to reduce mesangial cell contractility in diabetes and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-mediated cleavage of cytoskeletal actin plays a positive role in the process of morphological apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Picric acid methods greatly overestimate serum creatinine in mice: more accurate results with high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HSP27 and signaling to the actin cytoskeleton focus on "HSP27 expression regulates CCK-induced changes of the actin cytoskeleton in CHO-CCK-A cells"

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock proteins: endogenous modulators of apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38MAPK inhibitor SB203580 sensitizes human SNU-C4 colon cancer cells to exisulind-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of lipoxygenase 1 by phosphatidylcholine micelles-bound curcumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of renal lesions associated with diabetes by dietary curcumin in streptozotocin diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21073732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1472-6882-10-67

1 reference

Europe PubMed Central

29 July 2017

Dimensions Publication ID

1 reference

https://scigraph.springernature.com/pub.10.1186/1472-6882-10-67

9 September 2019

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

ResearchGate publication ID

0 references

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