Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models (Q33746410)

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9 March 2020

title

Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models (English)

1 reference

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9 March 2020

0 references

0 references

1 reference

1

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9 March 2020

Franz-Josef Müller

7

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9 March 2020

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Jeanne F Loring

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9 March 2020

author name string

Brian Spencer

2

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9 March 2020

Sara Michael

3

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9 March 2020

Nicholas A Castello

4

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9 March 2020

Andranik A Agazaryan

5

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9 March 2020

Joy L Davis

6

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9 March 2020

Frank M LaFerla

10

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9 March 2020

Eliezer Masliah

9

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9 March 2020

publication date

16 April 2014

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Stem Cell Research & Therapy

9 March 2020

published in

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9 March 2020

volume

5

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9 March 2020

issue

2

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9 March 2020

page(s)

46

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Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status

9 March 2020

cites work

1 reference

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Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain

14 July 2018

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Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

14 July 2018

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Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.

14 July 2018

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Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

14 July 2018

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Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

14 July 2018

1 reference

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Pathways by which Abeta facilitates tau pathology

14 July 2018

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Gene therapy: can neural stem cells deliver?

14 July 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

14 July 2018

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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

14 July 2018

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Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review

14 July 2018

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

14 July 2018

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CD10 in acute leukemias. GEIL (Groupe d'Etude Immunologique des Leucémies).

14 July 2018

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

14 July 2018

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

14 July 2018

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Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

21 January 2018

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Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamus

21 January 2018

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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

21 January 2018

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Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

21 January 2018

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Retinal transplantation of neural progenitor cells derived from the brain of GFP transgenic mice

21 January 2018

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Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

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Neural stem cells improve memory in an inducible mouse model of neuronal loss.

21 January 2018

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Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.

21 January 2018

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21 January 2018

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Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.

30 October 2018

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30 October 2018

Identifiers

DOI

10.1186/SCRT440

1 reference

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Dimensions Publication ID

9 March 2020

1 reference

https://scigraph.springernature.com/pub.10.1186/scrt440

9 September 2019

1 reference

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9 March 2020

PubMed publication ID

25022790

1 reference

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