Baicalin inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via the AKT/HIF-1α/p27-associated pathway (Q33755731)

29 July 2017

title

Baicalin inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via the AKT/HIF-1α/p27-associated pathway (English)

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29 July 2017

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1 reference

Lin Zhang

1

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29 July 2017

Zhichen Pu

2

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29 July 2017

Junsong Wang

3

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29 July 2017

Zhifeng Zhang

4

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29 July 2017

Dongmei Hu

5

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29 July 2017

Junjie Wang

6

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29 July 2017

language of work or name

English

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publication date

9 May 2014

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International Journal of Molecular Sciences

29 July 2017

published in

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29 July 2017

volume

15

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29 July 2017

issue

5

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29 July 2017

page(s)

8153-8168

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Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

9 May 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia

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Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats

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Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT.

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Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells

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Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells.

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Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest

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Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

21 June 2018

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Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension.

21 June 2018

1 reference

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Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes

21 January 2018

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Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia

21 January 2018

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Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery

21 January 2018

1 reference

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Baicalein protects rat cardiomyocytes from hypoxia/reoxygenation damage via a prooxidant mechanism.

21 January 2018

1 reference

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Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15058153

p27(Kip1) is important in modulating pulmonary artery smooth muscle cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15058153

p42/44 Mitogen-activated protein kinase regulated by p53 and nitric oxide in human pulmonary arterial smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15058153

Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS15058153

Primary pulmonary hypertension

21 January 2018

1 reference

12 December 2020

Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

1 reference

12 December 2020

p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice

1 reference

12 December 2020

Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice

1 reference

12 December 2020

Hypoxia-Inducible Factor-1 (HIF-1)

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12 December 2020

Identifiers

DOI

10.3390/IJMS15058153

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29 July 2017

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29 July 2017

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