Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives (Q33763090)

29 July 2017

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title

Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives (English)

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29 July 2017

butylated hydroxytoluene

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Williams GM

1

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PubMed ID

10541460

29 July 2017

Iatropoulos MJ

series ordinal

2

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PubMed ID

10541460

29 July 2017

Whysner J

series ordinal

3

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29 July 2017

1 September 1999

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Food and Chemical Toxicology

29 July 2017

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29 July 2017

37

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29 July 2017

9-10

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29 July 2017

1027-1038

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Chromosome aberrations and sister chromatid exchanges in Chinese hamster cells exposed to various chemicals

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Induction of early lesions in the forestomach of rats by 3-tert-butyl-4-hydroxyanisole (BHA)

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Adenomatous hyperplasia and adenomas in the lung induced by chronic feeding of butylated hydroxyanisole of Japanese house musk shrew (Suncus murinus).

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Nutrition and health aspects of free radicals and antioxidants

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Butylated hydroxytoluene (BHT): a review

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Hydroxylation of benzo[a]pyrene and binding of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene metabolites to deoxyribonucleic acid catalyzed by purified forms of rabbit liver microsomal cytochrome P-450. Effect of 7,8-benzoflavone, butylated hydro

1 reference

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7 January 2021

Differential protective effects of antioxidants against cell killing and mutagenesis of Salmonella typhimurium by gamma radiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Relationships between sister chromatid exchange and mutagenicity, toxicity and DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Cell culture assays for chemicals with tumor-promoting or tumor-inhibiting activity based on the modulation of intercellular communication.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Effects of butylated hydroxytoluene alone or with diethylnitrosamine in mice

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https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Selective Sex-Related Modification of Diethylnitrosamine-lnduced Carcinogenesis in BALB/c Mice by Concomitant Administration of Butylated Hydroxytoluene2

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https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Inhibition by butylated hydroxytoluene of excision repair synthesis and semiconservative DNA synthesis

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https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

In vitro system for detecting non-genotoxic carcinogens.

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https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Detection of chemical mutagens by the dominant lethal assay in the mouse

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https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Effect of butylated hydroxytoluene pretreatment on the excretion, tissue distribution and DNA binding of [14C]aflatoxin B1 in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin for promotion of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Studies on the mechanism of inhibition of 2-acetylaminofluorene toxicity by butylated hydroxytoluene

1 reference

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7 January 2021

Butylated hydroxyanisole, butylated hydroxytoluene and tert.-butylhydroquinone are not mutagenic in the Salmonella/microsome assay using new tester strains.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat. (II): Metabolism in forestomach and covalent binding to tissue macromolecules

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat (I): Excretion of BHA in urine, feces and expired air and distribution of BHA in the main organs

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Chronic toxicity of butylated hydroxytoluene in Wistar rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Chromosome tests with 134 compounds on Chinese hamster cells in vitro--a screening for chemical carcinogens

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Phenolic antioxidants: Health Protection Branch studies on butylated hydroxyanisole

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Synthetic antioxidants: biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Radiosensitizing Property of Butylated Hydroxytoluene inDrosophilaSperm

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites in short-term tests in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Modification of radiation-induced genetic damage in Drosophila melanogaster male germ cells by butylated hydroxytoluene

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Effects of butylated hydroxyanisole in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

DNA damage in forestomach epithelium from male F344 rats following oral administration of tert-butylquinone, one of the forestomach metabolites of 3-BHA

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Biological fate of butylated hydroxytoluene (BHT)-Binding of BHT to nucleic acid in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Carcinogenicity study on butylated hydroxytoluene (BHT) in Wistar rats exposed in utero

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Induction of hepatic tumors with butylated hydroxyanisole in the self-fertilizing hermaphroditic fish Rivulus ocellatus marmoratus.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Inhibition of the mutagenicity of benzo[a]pyrene in the V79/HGPRT system by bioantioxidants

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Microsome-mediated clatogenicity of butylated hydroxyanisole (BHA) in cultured Chinese hamster ovary cells: The possible role of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Radiosensitization ofDrosophilaSperm by Commonly Used Food Additives–Butylated Hydroxyanisole and Butylated Hydroxytoluene

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Lack of induction of sister chromatid exchanges and of mutation to 6-thioguanine resistance in V79 cells by butylated hydroxyanisole with and without activation by rat or hamster hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

DNA-adduct formation in the forestomach of rats treated with 3-tert-butyl-4-hydroxyanisole and its metabolites as assessed by an enzymatic 32P-postlabeling method

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

The effects of butylated hydroxytoluene on radiation and chemically-induced genetic damage in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Induction of oxidative DNA damages and enhancement of cell proliferation in human lymphocytes in vitro by butylated hydroxyanisole

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Induction of oxidative DNA damage and early lesions in rat gastro-intestinal epithelium in relation to prostaglandin H synthase-mediated metabolism of butylated hydroxyanisole.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

The role of prostaglandin H synthase-mediated metabolism in the induction of oxidative DNA damage by BHA metabolites.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Carcinogen-induced chromosomal breakage decreased by antioxidants

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Effect of phenolic antioxidants on the mutagenicity of aflatoxin B1

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Tests for mutagenic effects of ammoniated glycyrrhizin, butylated hydroxytoluene, and gum Arabic in rodent germ cells

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Lack of carcinogenicity of butylated hydroxytoluene on long-term administration to B6C3F1 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Acute, subchronic and chronic toxicity studies of a synthetic antioxidant, 2,2'-methylenebis(4-methyl-6-tert-butylphenol) in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Effects of four antioxidants on N-methyl-N'-nitro-N-nitrosoguanidine initiated gastric tumor development in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Microsome-mediated cytotoxicity to CHO cells

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Inhibitory effect of butylated hydroxytoluene (BHT) on intestinal carcinogenesis in rats by azoxymethane

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Dose response of promotion by butylated hydroxyanisole in chemically initiated tumours of the rat forestomach

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Butylated hydroxyanisole mechanistic data and risk assessment: conditional species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Liver carcinogenesis: The role for some chemicals of an epigenetic mechanism of liver-tumour promotion involving modification of the cell membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Epigenetic promoting effects of butylated hydroxyanisole

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Methods for evaluating chemical genotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Inhibition of chemical-induced experimental cancer by synthetic phenolic antioxidants

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Inhibition of the hepatocarcinogenicity of aflatoxin B1 in rats by low levels of the phenolic antioxidants butylated hydroxyanisole and butylated hydroxytoluene.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. I. Genetic and cellular effects

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. II. Chronic feeding studies

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Enhancement of urethan tumorigenesis in mouse lung by butylated hydroxytoluene.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

Study on mutagenicity and antimutagenicity of BHT and its derivatives in a bacterial assay.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900085-X

7 January 2021

10.1016/S0278-6915(99)00085-X

Identifiers

DOI

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29 July 2017

1 reference

PubMed ID

10541460