Modelling G-protein-coupled receptors for drug design (Q33766736)

29 July 2017

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title

Modelling G-protein-coupled receptors for drug design (English)

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G protein-coupled receptor

29 July 2017

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protein design

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author name string

D R Flower

series ordinal

1

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PubMed ID

10548717

29 July 2017

language of work or name

English

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publication date

1 November 1999

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Biochimica et Biophysica Acta

29 July 2017

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29 July 2017

1422

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29 July 2017

3

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29 July 2017

207-234

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G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Fingerprinting G-protein-coupled receptors

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https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The structure of bacteriorhodopsin and its relevance to the visual opsins and other seven-helix G-protein coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structural relationship of streptavidin to the calycin protein superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structure and sequence relationships in the lipocalins and related proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Receptors and G proteins as primary components of transmembrane signal transduction. Part 1. G-protein-coupled receptors: structure and function.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Chemokine receptors: keys to AIDS pathogenesis?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The area code hypothesis revisited: olfactory receptors and other related transmembrane receptors may function as the last digits in a cell surface code for assembling embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structure and function of G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Locating ligand-binding sites in 7TM receptors by protein engineering.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The family of G-protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

G-Protein coupled receptors: models, mutagenesis, and drug design.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The PRINTS protein fingerprint database in its fifth year.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

G protein-coupled receptors in silico.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Multiple sequence alignment of protein families showing low sequence homology: a methodological approach using database pattern-matching discriminators for G-protein-linked receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Design of a discriminating fingerprint for G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The PRINTS Database of Protein Fingerprints: A Novel Information Resource for Computational Molecular Biology

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structures of the extracellular domain of the type I tumor necrosis factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structure of porin refined at 1.8 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Overexpression of integral membrane proteins for structural studies

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Two-dimensional crystallization of membrane proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Quantitative evaluation of neurotensin receptor purification by immobilized metal affinity chromatography

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Lipid nanotubes as substrates for helical crystallization of macromolecules.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Submolecular resolution of single macromolecules with atomic force microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Projection structure of frog rhodopsin in two crystal forms

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Projection Structure of an Invertebrate Rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Arrangement of rhodopsin transmembrane α-helices

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structure of the third cytoplasmic loop of bovine rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structure of the carboxy-terminal domain of bovine rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The First and Second Cytoplasmic Loops of the G-Protein Receptor, Rhodopsin, Independently Form β-Turns†

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Three-Dimensional Structure of the Cytoplasmic Face of the G Protein Receptor Rhodopsin†

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Crystal structure of human chorionic gonadotropin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The 2.0 A crystal structure of a heterotrimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

G-protein diseases furnish a model for the turn-on switch

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Three-dimensional modelling of G protein-linked receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Re-evaluation of bacteriorhodopsin as a model for G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

This is not a G protein-coupled receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

An analysis of the conserved residues between halobacterial retinal proteins and G-protein coupled receptors: implications for GPCR modeling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Molecular dynamics of dopamine at the D2 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

An energy-based approach to packing the 7-helix bundle of bacteriorhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

A new approach to docking in the beta 2-adrenergic receptor that exploits the domain structure of G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The probable arrangement of the helices in G protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Combined biophysical and biochemical information confirms arrangement of transmembrane helices visible from the three-dimensional map of frog rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

BUNDLE: a program for building the transmembrane domains of G-protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Automated method for modeling seven-helix transmembrane receptors from experimental data

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structural basis of beta-adrenergic receptor function.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Biophysical and genetic analysis of the ligand-binding site of the β-adrenoceptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Functional mapping of the ligand binding sites of G-protein coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Identification of residues required for ligand binding to the beta-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Ligand binding to the beta-adrenergic receptor involves its rhodopsin-like core

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The role of the seventh transmembrane region in high affinity binding of a beta 2-selective agonist TA-2005

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The ligand binding site of the angiotensin AT1 receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

A review of mutagenesis studies of angiotensin II type 1 receptor, the three-dimensional receptor model in search of the agonist and antagonist binding site and the hypothesis of a receptor activation mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The docking of Arg2 of angiotensin II with Asp281 of AT1 receptor is essential for full agonism

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Interaction of Phe8 of angiotensin II with Lys199 and His256 of AT1 receptor in agonist activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Mutagenesis and the molecular modeling of the rat angiotensin II receptor (AT1)

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Interaction of biphenylimidazole and imidazoleacrylic acid nonpeptide antagonists with valine 108 in TM III of the AT1 angiotensin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Genetic transfer of a nonpeptide antagonist binding site to a previously unresponsive angiotensin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Identification of nonconserved amino acids in the AT1 receptor which comprise a general binding site for biphenylimidazole antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Shared determinants of receptor binding for subtype selective, and dual endothelin-angiotensin antagonists on the AT1 angiotensin II receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Non-peptide angiotensin agonist. Functional and molecular interaction with the AT1 receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structural model of antagonist and agonist binding to the angiotensin II, AT1 subtype, G protein coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

How different amino acid sequences determine similar protein structures: the structure and evolutionary dynamics of the globins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Measuring diversity: experimental design of combinatorial libraries for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Spiropiperidines as high-affinity, selective .sigma. ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

The arrangement of the transmembrane helices in the secretin receptor family of G-protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

G protein-coupled receptors. II. Mechanism of agonist activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Identification of a ligand-dependent switch within a muscarinic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Functional Microdomains in G-protein-coupled Receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

A three-state receptor model of agonist action

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Matching chemistry and shape in molecular docking

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Automated docking of flexible ligands: applications of AutoDock

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

A fast flexible docking method using an incremental construction algorithm.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Structure-based discovery of inhibitors of thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

An example of a protein ligand found by database mining: description of the docking method and its verification by a 2.3 A X-ray structure of a thrombin-ligand complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

1 reference

7 January 2021

Constructing protein models for ligand-receptor binding thermodynamic simulations: an application to a set of peptidometic renin inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

A virtual screening approach applied to the search for trypanothione reductase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Prediction of drug binding affinities by comparative binding energy analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Pseudo-receptor modeling: a new concept for the three-dimensional construction of receptor binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

On the interaction of the aromatic part of dopaminergic agonists with the receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Novel deltorphin heptapeptide analogs with potent delta agonist, delta antagonist, or mixed mu antagonist/delta agonist properties

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

ALTER: eclectic management of molecular structure data

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4157%2899%2900006-4

7 January 2021

10.1016/S0304-4157(99)00006-4

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10548717