Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid (Q33774977)

29 July 2017

title

Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid (English)

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29 July 2017

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7

Asim K Debnath

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29 July 2017

1

Francesca Curreli

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29 July 2017

Hongtao Zhang

2

1 reference

29 July 2017

Xihui Zhang

3

1 reference

29 July 2017

Ilya Pyatkin

4

1 reference

29 July 2017

Zagorodnikov Victor

5

1 reference

29 July 2017

Andrea Altieri

6

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29 July 2017

language of work or name

English

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publication date

25 November 2010

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Bioorganic & Medicinal Chemistry

29 July 2017

published in

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29 July 2017

volume

19

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29 July 2017

issue

1

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29 July 2017

page(s)

77-90

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Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors

29 July 2017

cites work

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Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection

4 July 2018

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4 July 2018

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

4 July 2018

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4 July 2018

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4 July 2018

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Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag

4 July 2018

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4 July 2018

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Mutation of dileucine-like motifs in the human immunodeficiency virus type 1 capsid disrupts virus assembly, gag-gag interactions, gag-membrane binding, and virion maturation

4 July 2018

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3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro

4 July 2018

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A domain directly C-terminal to the major homology region of human immunodeficiency type 1 capsid protein plays a crucial role in directing both virus assembly and incorporation of Gag-Pol

4 July 2018

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The Mechanism of HIV-1 Core Assembly: Insights from Three-Dimensional Reconstructions of Authentic Virions

4 July 2018

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The retroviral capsid domain dictates virion size, morphology, and coassembly of gag into virus-like particles

4 July 2018

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4 July 2018

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The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV.

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Selected amino acid substitutions in the C-terminal region of human immunodeficiency virus type 1 capsid protein affect virus assembly and release.

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein

4 July 2018

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Structural organization of authentic, mature HIV-1 virions and cores

4 July 2018

1 reference

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Tripeptide interference with human immunodeficiency virus type 1 morphogenesis

4 July 2018

1 reference

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Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

Drug-like properties and the causes of poor solubility and poor permeability

4 July 2018

1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

Image reconstructions of helical assemblies of the HIV-1 CA protein

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

In vitro assembly properties of purified bacterially expressed capsid proteins of human immunodeficiency virus

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

Blocking HIV-1 virus assembly

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

Electrostatic repulsion, compensatory mutations, and long-range non-additive effects at the dimerization interface of the HIV capsid protein

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

The dimerization domain of the HIV-1 capsid protein binds a capsid protein-derived peptide: a biophysical characterization

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

Antiviral inhibition of the HIV-1 capsid protein

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

Assembly and analysis of conical models for the HIV-1 core.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

Inhibition of infectious human immunodeficiency virus type 1 particle formation by Gag protein-derived peptides

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034313

1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21168336

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Investigation of N-terminal domain charged residues on the assembly and stability of HIV-1 CA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21168336

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21168336

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMC.2010.11.045

1 reference

29 July 2017

1 reference

29 July 2017

1 reference