The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release (Q33775446)

29 July 2017

title

The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release (English)

1 reference

29 July 2017

Baohua Huang

1

1 reference

29 July 2017

Ankur Desai

2

1 reference

29 July 2017

Shengzhuang Tang

3

1 reference

29 July 2017

Thommey P Thomas

4

1 reference

29 July 2017

James R Baker

5

1 reference

29 July 2017

language of work or name

English

0 references

publication date

1 April 2010

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29 July 2017

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29 July 2017

volume

12

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29 July 2017

issue

7

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29 July 2017

page(s)

1384-1387

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Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851157

Novel prodrugs of SN38 using multiarm poly(ethylene glycol) linkers

4 July 2018

1 reference

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Tumor angiogenic vasculature targeting with PAMAM dendrimer-RGD conjugates

4 July 2018

1 reference

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Exploiting tumour hypoxia in cancer treatment

4 July 2018

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Specialization of tumour vasculature

4 July 2018

1 reference

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Targeted prodrug design to optimize drug delivery

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851157

Irinotecan in the treatment of colorectal cancer: clinical overview

4 July 2018

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2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo

4 July 2018

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The clinical status of irinotecan (CPT-11), a novel water soluble camptothecin analogue: 1996.

4 July 2018

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Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide

4 July 2018

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Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase.

4 July 2018

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Tumour vasculature--a potential therapeutic target

4 July 2018

1 reference

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Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1.

4 July 2018

1 reference

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Liposomalization of SN-38 as active metabolite of CPT-11.

4 July 2018

1 reference

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Synthesis and biological evaluation of a (99m)Tc-labelled cyclic RGD peptide for imaging the alphavbeta3 expression

30 October 2018

1 reference

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Integrin targeting using RGD-PEI conjugates for in vitro gene transfer

30 October 2018

1 reference

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Design, synthesis, and biological evaluation of indolequinone phosphoramidate prodrugs targeted to DT-diaphorase

30 October 2018

1 reference

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Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release

30 October 2018

1 reference

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Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.

30 October 2018

1 reference

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Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851157

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20192275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Electron transfer reactions in RB90745, a bioreductive drug having both aromatic N-oxide and nitroarene moieties

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20192275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cyclization-activated prodrugs. Basic carbamates of 4-hydroxyanisole

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20192275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/OL1002626

1 reference

29 July 2017

1 reference

29 July 2017

1 reference