Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. (Q33775531)

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2 January 2020

title

Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis (English)

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2 January 2020

1

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Ajay Goel

2

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2 January 2020

author name string

Kenji Notohara

3

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2 January 2020

Takaomi Takahata

4

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2 January 2020

Hiromi Sasamoto

5

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2 January 2020

Takuyuki Uchida

6

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2 January 2020

Naoshi Nishida

7

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2 January 2020

Noriaki Tanaka

8

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2 January 2020

Clement Richard Boland

9

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2 January 2020

Nagahide Matsubara

10

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2 January 2020

language of work or name

English

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publication date

1 June 2008

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International Journal of Cancer

2 January 2020

published in

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2 January 2020

volume

122

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issue

11

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2 January 2020

page(s)

2429-2436

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An elaborate pathway required for Ras-mediated epigenetic silencing

2 January 2020

cites work

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4 July 2018

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O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions

4 July 2018

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4 July 2018

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Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

4 July 2018

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Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer

4 July 2018

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P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.

4 July 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

4 July 2018

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Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression.

4 July 2018

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Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene

4 July 2018

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4 July 2018

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Genetic alterations during colorectal-tumor development

4 July 2018

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Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents

4 July 2018

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Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

4 July 2018

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Expression of the endogenous O6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions

4 July 2018

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Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas

4 July 2018

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Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases.

30 October 2018

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Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression.

30 October 2018

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Low-level microsatellite instability in most colorectal carcinomas

30 October 2018

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Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.

30 October 2018

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Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability.

30 October 2018

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Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis

30 October 2018

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis

30 October 2018

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

30 October 2018

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In vitro methylation of the human O6-methylguanine-DNA methyltransferase promoter reduces transcription

30 October 2018

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12 December 2020

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene

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12 December 2020

Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation

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12 December 2020

Detection and interpretation of altered methylation patterns in cancer cells

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12 December 2020

Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability

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12 December 2020

Identifiers

DOI

10.1002/IJC.23398

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18240147%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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2 January 2020

PubMed publication ID

18240147

1 reference